21.Lycopene Ameliorates Glycemic Control in Fructose Induced Diabetes Mellitus in Wistar Albino Rats
Jawad Mumtaz Sodhar1, Shagufta Memon3, Majid Ali Hingoro4, Palwasha Abbasi5, Mashal Siddiqui6 and Umair Ali Soomro2
ABSTRACT
Objective: Experiment determining the blood glucose regulating effects of lycopene in high fructose fed diet (HFD) induced diabetes mellitus (DM) in Male Albino Wistar Rat.
Study Design: An Experimental study
Place and Duration of Study: This study was conducted at the Departments of Basic Medical Sciences, Suleman Roshan Medical College, Tando Adam from April 2021 to September 2021 for a period of six months.
Materials and Methods: Sixty male Wistar albino rats were divided into –ve and +ve controls (groups A and B) and Experimental groups – HFD induced DM treated with lycopene (groups C and D). Each group comprised 15 rats. DM was induced by feeding HFD (21% w/v) till induction of fructose. Glycemic and lipid variables were estimated by standard biochemical analysis from the blood sera of rats. Data was analyzed in SPSS 21.0 (IBM, Incorporation, USA) at 95% CI (P<0.05).
Results: Lycopene therapy improves the RBS, FBS and HbA1c% in experimental rats. Lycopene therapy also reduced the serum cholesterol, triglycerides and LDLc with rise in serum HDLc concomitantly (P=0.0001).
Conclusion: In conclusion, the lycopene therapy improves blood glucose and lipid level in high fructose diet induced diabetes mellitus in rat model.
Key Words: Lycopene, Fructose, Glycemic control, Lipids, Rats
Citation of article: Sodhar JM, Memon S, Hingoro MA, Abbasi P, Siddiqui M, Soomro UA. Lycopene Ameliorates Glycemic Control in Fructose Induced Diabetes Mellitus in Wistar Albino Rats. Med Forum 2022;33(3):86-90.