21.Effects of OMEGA 3 PUFA Treatment on Alanine Aminotransferase in Patients with Nonalcoholic Fatty Liver Disease
Rehan Sarwar1, Syed Saif Ur Rehman1, Ayesha Aftab2, Muhammad Wajad Munir1 and
Abida Mateen1
ABSTRACT
Objective: To determine the efficacy of omega 3 PUFA in lowering Alanine Aminotransferase (ALT) levels in Nonalcoholic fatty liver disease (NAFLD).
Study Design: Prospective interventional study
Place and Duration of Study: This study was conducted at the Department of Medicine of Al- Nafees Medical College & Hospital, Islamabad from April, 2018 to September, 2018.
Materials and Methods: After hospital ethical committee approval the study was conducted and informed written consent was taken. Patients with evidence of fatty liver were selected by ultrasonography after fulfilling of inclusion criteria and sub categorized on the basis of gender and age. Alanine Aminotransferase levels and fasting lipid profile were performed. Omega 3 PUFA were given to these subjects for 6 months, ALT and fasting lipid profile were checked at 3rd month and 6th month. Collected information was analyzed by using SPSS 23 version.
Results: Total 40 patients were selected in which 25 (62.5 %) were female in our study and 15 (37.5 %) were male. The mean age of patients in our study was 45.98 ± 9.13. Primary outcome of the study was the mean value of Alanine Aminotransferase ALT before treatment was 114.95 ± 33.47, after 3rd month was 67.23 ± 27.86 and after 6th month was 47.95 ± 14.98. Secondary outcome was serum lipid profile. The mean value of cholesterol before treatment was 195.45 ± 30.37, after 3rd month was 187.38 ± 25.34 and after 6th month was 180.35 ± 14.53. The mean value of triglycerides before treatment was 235.35 ± 67.52, after 3rd month was 212.68 ± 53.92 and after 6th month was 201.88 ± 42.33.The mean value of HDL before treatment was 49.80 ± 5.77, after 3rd month was 52.75 ± 5.62 and after 6th month was 55.93 ± 4.98.
Conclusion: Omega 3 PUFA is effective in reduction of liver enzymes Alanine Aminotransferase (ALT), liver fat, levels of blood cholesterol and triglycerides with elevation of HDL in Non-Alcoholic Fatty Liver Disease (NAFLD) patients.
Key Words: Alanine Aminotransferase, Cholesterol, Non-alcoholic fatty liver disease, Omega 3 PUFA, Triglycerides.
Citation of article: Sarwar R, Rehman SS, Aftab A, Munir MW, Mateen A. Effects of OMEGA 3 PUFA Treatment on Alanine Aminotransferase in Patients with Nonalcoholic Fatty Liver Disease. Med Forum 2022;33(10):92-95.