21. To Compare Frequency of Pre- Eclampsia in Pregnant Women with or Without Persistent Early Diastolic Notch on Uterine Artery Doppler at 24 Weeks of Gestation
Shumaila Kiran, Zoya Khan, Muzimmal Zulfquar Bhatti and Saima Ashraf
ABSTRACT
Objective: To compare frequency of pre-eclampsia in pregnant women with or without persistent early diastolic
notch on uterine artery Doppler at 24 weeks of gestation.
Study Design: Comparative study.
Place and Duration of Study: This study was conducted at the Outpatient Department of Obstetrics & Gynecology Nishtar Hospital Multan from May 2015 to May 2016.
Materials and Methods: A total of 148 pregnant women fulfilling inclusion and exclusion criteria were enrolled for the study. Informed consent was obtained from all the patients by explaining the procedure and its outcome and ensured of their confidentiality. Study was conducted after approval from ethical committee of the institution. A detailed history including demography of the patients like name, age and address was recorded. In all women, Doppler flow rate wave forms at the portion of the uterine artery on the side of uterus were recorded. Resistance index and pulsatility index values of right and left uterine arteries were evaluated separately. After having wave form obtained at 24 weeks gestation, according to presence of EDN, cases were divided into two groups. Group A consisted of 74 women without early diastolic notch (unexposed group) and Group B of 74 women with early diastolic notch (exposed group). Then these pregnancies were followed until birth.
Results: In our study, out of 148 cases (74 in each group) 58.11%(n=43) in Group-A and 63.51%(n=47) in Group-B were between 21-30 years while 41.89%(n=31) in Group-A and 36.49%(n=27) in Group-B were between 31-35 years of age, mean+sd was calculated as 28.22+4.91 and 27.69+4.83 respectively. Comparison of pre-eclamsia in both groups was done which shows that 4.05%(n=3) in Group-A and 18.92%(n=14) in Group-B had pre-eclampsia while remaining 95.95%(n=71) in Group-A and 81.08%(n=60) in Group-B had no findings of the morbidity, p value was calculated as 0.004 which shows a significant difference between the two group, Relative Risk= 0.2143.
Conclusion: We concluded that the frequency of pre-eclampsia in pregnant women is significantly higher in patients with persistent early diastolic notch on uterine artery Doppler at 24 weeks of gestation as compare to those having no diastolic notch.
Key Words: Persistent early diastolic notch, diagnosis, pre-eclampsia.
Citation of articles: Kiran S, Khan Z, Bhatti MZ, Ashraf S. To Compare Frequency of Pre-Eclampsia In Pregnant Women with or Without Persistent Early Diastolic Notch on Uterine Artery Doppler at 24 Weeks of Gestation. Med Forum 2017;28(10):85-88.