21. Comparative Immunohistochemical Staining for Chromogranin A and Synaptophysin in Intestinal Carcinoids
Zabihullah1, Rania Hidayat1, Shaista Alam2, Shabir Ahmed Orakzai3, Amara Hayat Awan4 and Humaira Khan2
ABSTRACT
Objective: To study the immunohistochemical staining for Chromogranin A and Synaptophysin in Intestinal Carcinoids.
Study Design: Cross sectional study
Place and Duration of Study: This study was conducted at the Ayub Teaching Hospital Abbotabad collected between 2017 to 2019.
Materials and Methods: Intestinal wall endocrine glands also seem to be optimistic for immunohistochemical chromogranin A known as CgA and synaptophysin known as SPY, the much more generally utilized stripes for neuron endo chemical cell types as well as tumors. Immunostaining CgA and SPY were conducted with four duodenal, fourteen ideals, five appendices, and seventeen colorectal. CgA with or without invasion of intestinal walls were strongly positive for duodenal and ileal carcinoids. CgA and SPY were weakly immuno-immunized in smaller appendix carcinoids.
Results: In particular, colorectal carcinoids with a low-grade tumor less than 1 centimeters with CgA negative coloration were more aggressive, whereas the bigger tumors less than 2 centimeters that infiltrate through the wall with often CIA's positive coloration. Duodenum, small gut, and colorectal CgA-positive carcinoids seem to be much attacking than CgA-negative tumors, most of which were just less than two centimeter, respectively. In the case of CgA with high serum CgA, while rectal hindgut cancers with low polyploidy tumors are CgA-negative but SPY-positive.
Conclusion: CgA-positive immunostaining can be used for gastroenteropancreatic neuroendocrine tumors, as an independent marker for potential malignancy, concerning the position and sort of the tumors. The immunostaining of CgA and SPY thus provides important carcinoid information.
Key Words: Carcinoid, Chromogranin A, Immunohistochemistry, Synatophysin
Citation of article: Zabihullah, Hidayat R, Alam S, Orakzai SA, Awan AH, Khan H. Comparative Immunohistochemical Staining for Chromogranin A and Synaptophysin in Intestinal Carcinoids. Med Forum 2021;32(6):83-86.