21. Association Between Serum Ferritin Levels and Lung Functions Among Iron Deficient Anemic Adults
Aliya Waseem1, Mohammad Saleh Soomro2, Shahjabeen3, Syed Adnan Ahmed1 and Saba Abrar1 and Tabinda1
ABSTRACT
Objective: Assessment of association between Serum Ferritin levels and lung function tests (FVC, FEV1, FEV1/FVC Ratio) in iron deficient anemic adults. Comparison of correlation between Serum Ferritin levels and Lung functions among iron deficient anemic and non-anemic adults.
Study Design: Case Control study
Place and Duration of Study: This study was conducted at the Fatima Hospital, Baqai Medical University Hospital, Karachi and Abbasi Shaheed Hospital, Karachi from July 2017 to December 2017.
Materials and Methods: 100 males and 100 female diagnosed iron deficient anemic adults in range of 18-45 years and with no co-morbid respiratory and cardiac diseases were included. Inclusion criteria also included iron deficient anemic adults with no acute emergency states and no chest and back area deformities. Blood samples were reanalyzed for blood Hemoglobin (Hb) by automated cell analyzer and iron deficiency anemia (IDA) was rechecked and confirmed by further tests like serum iron, serum ferritin, serum Total iron binding capacity (TIBC) levels by Enyme linked immunosorbent assay (ELISA). Pulmonary function tests(PFTs) i.e. Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1st second (FEV1) were measured by Digital Spirometer in all anemic patients and lung functions were compared with lung functions of non-anemic healthy individuals.
Results: There was significant reduction (p<0.05) in FVC and FEV1 in male and female iron deficient anemic cases than in male and female controls respectively. Whereas the FEV1/FVC ratio was significantly increased (p<0.05) in male and female cases. Restrictive lung changes were observed in male and female cases. Mean value of serum ferritin in male and female iron deficient anemic subjects were significantly lower (p<0.05) than in male and female controls respectively. Positive association between serum ferritin levels and lung function changes were found in the anemic group. While the non-anemic healthy participants showed no abnormal lung functions.
Conclusion: The results showed restrictive lung function changes in iron deficient anemic group. Positive association was observed between serum ferritin levels and lung function changes in the anemic subjects. No abnormal changes in lung functions were found in healthy controls.
Key Words: Hemoglobin, Iron Deficiency Anemia, Serum Ferritin, Pulmonary function tests, Forced Vital Capacity, Forced Expiratory Volume in 1st second.
Citation of article: Waseem A, Soomro MS, Shahjabeen, Ahmed SA, Abrar S, Tabinda. Association Between Serum Ferritin Levels and Lung Functions Among Iron Deficient Anemic Adults. Med Forum 2020;31(10):92-96.