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  3. 20.Diagnostic Accuracy of Strain Ultrasound Elastography in Differentiating Benign and Malignant Thyroid Nodules, Taking Histopathology as the Gold Standard
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20.Diagnostic Accuracy of Strain Ultrasound Elastography in Differentiating Benign and Malignant Thyroid Nodules, Taking Histopathology as the Gold Standard

Malik Mudasir Hassan1, Kamran Naseem1, Tanzeela Akram2, Aqsa Ashraf Bukhari3 and Ifrah Zafar3

ABSTRACT

Objective: To evaluate the diagnostic accuracy of strain Ultrasound elastography in differentiating malignant and benign thyroid nodules.

Study Design: A descriptive cross-sectional study

Place and Duration of Study: This study was conducted at the Radiology department of Bahawal Victoria Hospital Bahawalpur from Feb 2020 to Feb 2021 for a period of one year.

Materials and Methods: A total of 80 patients with palpable thyroid nodules were included after passing through selection criteria. Strain ultrasound elastography was done to distinguish benign and malignant lesions in all patients. The findings were compared with the results of histopathology testing.

Results: The mean age of participants was 46.5± 6.21 years. Out of 80 patients, 43 (53.7%) were male and 37 (46.2%) were female. Mean disease duration was 8.71± 4.52 months and mean nodular size was 4.38±1.50 cm. The strain USG confirmed positivity for malignancy in 40 cases while the other 40 were regarded negative for any malignancy.  In comparison with histopathology findings, 3 were found to be false-positive and 2 were false negative. On adjusting the confounding variables, strain USG was found to be 95% sensitive, 90.5% specific, had PPV of 90.8%, NPV of 94.1%, and was 93% accurate in terms of differentiating benign from malignant thyroid tumors on comparison with histopathology.

Conclusion: Strain ultrasound elastography is a non-invasive technique with a considerable diagnostic accuracy of differentiating benign and malignant thyroid nodules when compared with gold-standard histopathology.

Key Words: Ultrasound Strain elastography, thyroid nodules, histopathology, malignancy

Citation of article: Hassan MM, Naseem K, Akram T, Bukhari AA, Zafar I. Diagnostic Accuracy of Strain Ultrasound Elastography in Differentiating Benign and Malignant Thyroid Nodules, Taking Histopathology as the Gold Standard. Med Forum 2021;32(12):85-89.