20. Vitamin D, Parathyroid Hormone and Metabolic Syndromes in Morbidly Obese Children
Sana Javaid, Zukhruf Maryam, Maroofa Habib
ABSTRACT
Objective: To observe the association of the parathyroid hormone and vitamin-D with the occurrence of metabolic syndromes in severely obese children.
Study Design: A prospective observational study
Place and Duration of Study: This study was conducted at the Department Pediatric Medicine of Nishtar medical university and hospital, Multan from July, 2018 to December, 2018.
Materials and Methods: Age, BMI, gender, serum vitamin-D, parathyroid hormone level, serum calcium, total cholesterol, HDL, LDL, triglycerides, fasting blood glucose and presence or absence of metabolic syndrome were equated between the two groups of the patients, taking normal or low vitamin-D levels as grouping variable. Then, the comparison was done taking normal or high PTH levels as grouping variable. Chi-square and student t tests were applied accordingly. The dissimilarities were reflected statistically significant if the p≤0.05.
Results: Out of 58, 37 children had low vitamin-D while 21 children had normal vitamin-D levels. The prevalence of metabolic syndromes was 75.7% and 33.3% in the children with low and normal vitamin-D levels, respectively (p=0.002); and differences in serum calcium, PTH, vitamin-D, total cholesterol, HDL, LDL and triglycerides were statistically significant (p≤0.05). Thirty five children had high PTH levels while 23 children had normal PTH levels. The prevalence of metabolic syndromes was 62.8% 56.5% in the children with high and normal PTH levels, respectively (p=0.629); and differences in serum PTH, vitamin-D, HDL and triglycerides were statistically significant (p≤0.05).
Conclusion: Vitamin-D, but not parathyroid hormone, is considerably associated with the occurrence of the metabolic syndromes in severely obese children.
Key Words: Vitamin-D, parathyroid hormone (PTH), obesity, children, metabolic syndromes.
Citation of articles: Sana Javaid, Zukhruf Maryam, Maroofa Habib Vitamin D, Parathyroid Hormone and Metabolic Syndromes in Morbidly Obese Children. Med Forum 2019;20(1):81-85.