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20. Exploring the Clinicopathological Attributes and Surgical Approaches in Cases of Papillary Thyroid Carcinoma Occurring Concurrently with Hashimotos Thyroiditis
Salman Ahmed Mangrio1, Mohammad Naeem2, Shabina Jaffar2, Khadija2, Muhammad Khurram Zia3 and M. Tahir Shah4
ABSTRACT
Objective: The main objective of the study is to exploring the clinicopathological attributes and surgical approaches in cases of papillary thyroid carcinoma occurring concurrently with hashimoto's thyroiditis.
Study Design: A retrospective cohort study
Place and Duration of Study: This study was conducted at the Dow University of Health Sciences, Karachi from August, 2017 to July, 2023.
Methods: A total of 180 patients diagnosed with both PTC and HT were included in the study. The data collection process involved the extraction of critical clinicopathological attributes, including demographic data such as age and gender, clinical history relevant to thyroid disease, and laboratory results pertaining to thyroid function and autoimmune markers.
Results: Data was collected from 180 patients from both genders. The mean age of the study population was 52.4±9.7 years, with age range from 30 to 75 years. The gender distribution was 72% female and 28% male among the study participants. Among the study population, 68% of patients had multifocal PTC. Lymph node involvement was detected in 42% of cases. The most common histological variant of PTC in this cohort was classical (73%), followed by follicular variant (19%) and tall cell variant (8%). The mean tumor size was 1.8±0.9 cm, with a range from 0.5 cm to 4.0 cm.
Conclusion: It is concluded that, our study highlights the clinicopathological attributes and surgical strategies in patients with concurrent papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT). The findings emphasize the multifaceted nature of these cases, with multifocality and lymph node involvement being common.
Key Words: Patients, Tumor, Thyroid, Lymphoma, Disease, Carcinoma