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  3. 19. Efficacy of Pimecrolimus Cream and Triamcinolone Acetonide Paste in the Treatment of Symptomatic Oral Lichen Planus
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19. Efficacy of Pimecrolimus Cream and Triamcinolone Acetonide Paste in the Treatment of Symptomatic Oral Lichen Planus

Hafiz Muhammad Aamir Riaz, Ayesha Shakeel, Maryam Ali Shaheen and Khurram Jaa

 

ABSTRACT

 

Objective: To compare the efficacy of pimecrolimus cream and triamcinolone acetone paste in the treatment of symptomatic oral lichen planus.

 

Study design: Randomized control trail.

 

Place and Duration of study: This study was conducted at the Dental Section, Allied Hospital, Faisalabad, from 3rd June 2016 to 31 December 2016.

 

Materials and Methods: Total no. of 36 patients was included in this study. Consecutive non probability sampling technique was used to calculate the sample size from the reference study by Farzam Gorouhi et al. Ethical approval was obtained from hospital ethical committee and informed consent was taken from the patients before the start of the study. Thirty six patients were randomly divided into two equal groups, eighteen patients in each group Primary outcome was measured by the difference of severity of pain by visual analogue scale at two months from baseline. Oral Health Impact Profile, clinical score and occurrence of side effects were the secondary outcomes measured at each treatment and follow up visit. Computer software SPSS version 23 was used to analyze the data. Data obtained at the end of the treatment in the form of visual analogue scale score, oral health impact profile scores and clinical scores, was compared with baseline scores. Chi square and T test was applied to find out the associated significance variables among the groups.

 

Results: Overall, there were 100% (n=36) patients; the study population was subdivided into two groups; group A (Pimecrolimus) and group B (Triamcinolone). The mean age, disease duration, VAS pain score, OHIP score and clinical score of the patients in group A was 44.50±6.20 years, 10.61±6.26 days, 5.72±2.32, 3.27±1.17 and 2.38±1.03 respectively, while the mean age, disease duration, VAS pain score, OHIP score and clinical score of the patients in group B was 45.72±5.35 years, 16.77±5.49 days, 6.77±1.43, 3.5±1.42 and 2.83±1.15 respectively. The mean VAS pain score after 1, 2 and 4 months, in group A, was 5.33±1.37, 3.83±1.29 and 3.22±1.39 respectively, while the mean VAS pain score after 1, 2 and 4 months, in group B, was 6.72±1.32, 5.33±1.28 and 4.0±1.57 respectively. The mean OHIP score after 1, 2 and 4 months, in group A, was 1.20±0.90, 2.10±1.42 and 1.45±1.03 respectively, while the mean OHIP score after 1, 2 and 4 months, in group B, was 1.26±1.04, 2.41±1.23 and 1.45±1.08 respectively. The mean clinical score after 1, 2 and 4 months, in group A, was 0.31±0.18, 0.95±0.36 and

 

0.58±0.44 respectively while the mean clinical score after 1, 2 and 4 months in group B was 0.31±0.16, 0.79±0.23 and 0.51±0.53 respectively. There was significant difference between groups on the basis of VAS score, OHIP score and Clinical score.

 

Conclusion: According to our study there is significant difference between the efficacy of pimecrolimus cream and triamcinolone acetonide paste, when used for treatment of symptomatic OLP with pimecrolimus cream scoring better than triamcinolone acetonide paste.

 

Key Words: Lichen planus, Pimecrolimus, Triamcinolone acetonide

 

Citation of articles: Riaz HMA, Shakeel A, Shaheen MA, Jaa K. Efficacy of Pimecrolimus Cream and Triamcinolone Acetonide Paste in the Treatment of Symptomatic Oral Lichen Planus. Med Forum 2017;28(12):76-80.