19. Effectiveness of Triamcinolone Acetonide Vs. Combination of Triamcinolone Acetonide and Betamethasone Dipropionate in Oral Lichen Planus. A Comparative Study
Muhammad Adeel1, Shakeel Ahmad2, Sana Zafar3, Danish Javed4, Hira Shafique5 and Nayab Khalid6
ABSTRACT
Objective: The purpose of this study is to see if the combination therapy of topical triamcinolone acetonide and betamethasone dipropionate is more effective as compared to the alone use of topical triamcinolone acetonide or not.
Study Design: Prospective Study
Place and Duration of Study: This study was conducted at the Tertiary Care Hospital setting from February 2020 to January 2021 for a period of 11 months.
Materials and Methods: Two groups i.e., Group A and Group B were made by randomly dividing the patients. Group A received 0.1% Triamcinolone acetonide while Group B received combination of triamcinolone acetonide 0.1% and betamethasone dipropionate 0.05%. Patients were instructed to apply the medication three times a day and then followed up after 2 weeks, first month, second month and third month respectively. At each visit, size of the lesion and symptoms were evaluated and the data collected was analyzed.
Results: Combination of triamcinolone acetonide 0.1% and betamethasone dipropionate 0.05% is found better in improving the symptoms of oral lichen planus and reducing the size of the lesion as compared to the alone 0.1% triamcinolone acetonide. Combination therapy has also provided better complete resolution of the lesion.
Conclusion: The authors concluded that combination drug therapy has better results as compared to the single drug therapy in cases of oral lichen planus. Due to the ongoing research in this domain newer drugs and their combinations are being proposed for treatment of oral lichen planus. According to the study, combination of triamcinolone and betamethasone provided better relief as compared to the alone triamcinolone. It will be a cost effective and reasonable combination as well as compared to the other newly developed costly alternatives.
Key Words: Oral lichen planus, betamethasone dipropionate, triamcinolone acetonide, oral cavity.
Citation of article: Adeel M, Ahmad S, Zafar S, Javed D, Shafique H, Khalid N. Effectiveness of Triamcinolone Acetonide Vs. Combination of Triamcinolone Acetonide and Betamethasone Dipropionate in Oral Lichen Planus. A Comparative Study. Med Forum 2021;32(6):75-78.