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  3. 19. Comparison of Intrauterine Versus Per-Rectal Misoprostol in the Prevention of Postpartum Haemorrhage During Caesarean Section
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19. Comparison of Intrauterine Versus Per-Rectal Misoprostol in the Prevention of Postpartum Haemorrhage During Caesarean Section

Original Article

Intrauterine VS Per-Rectal Misoprostol in PPH During CS

Comparison of Intrauterine Versus Per-Rectal Misoprostol in the Prevention of Postpartum Haemorrhage During
Caesarean Section

Maryam Shoaib1, Firdous Ara1, Momy Gul1, Rehana Kamal1, Samia Saifullah1 and
Arifa Inayat2

ABSTRACT

Objective: Current study is aimed to compare the frequency of postpartum haemorrhage in high-risk females undergoing caesarean sections who receive either intrauterine or per-rectal misoprostol.

Study Design: Prospective observational study

Place and Duration of Study: This study was conducted at the Sandeman Provincial Hospital Quetta during March 2022 till October 2022.

Methods: In this study, a total of 170 women undergoing caesarean section were randomly distributed into two study groups. Group A received 400 mg of intrauterine misoprostol, while Group B received 400 mg of per-rectal misoprostol. Maternal outcomes such as blood loss, haemoglobin difference, duration of surgery, and need for blood transfusion were compared. Neonatal outcomes and adverse events like fever, nausea, shivering, and headache were also assessed.

Results: The mean value of lost blood was significantly lesser in Group A (670 ± 190 mL) compared to Group B (750 ± 210 mL) (p = 0.04). The haemoglobin change was also less in Group A (0.85 ± 0.65 g/dL) versus Group B (1.05 ± 0.75 g/dL) (p = 0.03). Adverse events like shivering were more common in Group A (19% vs. 4%, p = 0.001).

Conclusion: There were no significant differences between the groups in terms of the need for blood transfusion or neonatal outcomes. Misoprostol effectively managed PPH via both administration routes, but intrauterine misoprostol significantly reduced intraoperative and postoperative blood loss compared to the rectal route, with temporary shivering as the only notable side effect.

Key Words: Postpartum Hemorrhage (PPH), Intrauterine Misoprostol, Rectal Misoprostol, Cesarean Section (CS)

Citation of article: Shoaib M, Ara F, Gul M, Kamal R, Saifullah S, Inayat A, Comparison of Intrauterine Versus Per-Rectal Misoprostol in the Prevention of Postpartum Haemorrhage During Caesarean Section. Med Forum 2024;35(10):84-88. doi:10.60110/medforum.351019.