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19. Association Between Serum Uric Acid and Lipid Profile in Adult Individuals
Roomisa Anis1, Ayesha Shafqat2, Rashad Mahmood4, Saeed Ahmed5, Wajahat Ullah Khan6 and Rana Tauqir Ullah Khan3
ABSTRACT
Objective: The objective of this study to determine Association between Serum Uric Acid and Lipid Profile in Adult Individuals
Study Design: Cross-sectional study
Place and Duration of Study: This study was conducted at the Department of Biochemistry, Al Nafees Medical College Islamabad and Mohi-Ud-Din Islamic Medical College, Mirpur AJ&K from February 2021 to
August 2022.
Materials and Methods: The research involved 300 adult participants, consisting of 150 males and 150 females, who were all in good health with no significant cardiovascular conditions. Prior to enrollment, informed consent was obtained from all participants, and the study protocol received approval from the internal Ethics Committee. Exclusion criteria encompassed individuals with myeloproliferative disorders, those undergoing cytotoxic drug therapy, pregnant or lactating women, individuals on diuretics, anti-hypertensive, or hypolipidemic medications, alcoholics, people with known cardiovascular, renal, or hepatic disorders, and those receiving anti-gout therapy. Blood samples were collected from both groups and underwent centrifugation at 3000 RPM for 10 minutes to obtain serum. Automatic chemical analyzers were used to analyze the serum samples, employing Merk kits for estimation. Additionally, biochemical tests were performed on female participants from both groups, including sugar levels, lipid profile, serum creatinine (Cr), blood urea nitrogen (BUN), and uric acid (UA). Statistical analysis was carried out using SPSS version 20 software.
Results: Significant differences were observed in the average levels of serum uric acid (SUA), triglycerides (TG), and high-density lipoprotein (HDL) between the male and female groups. According to the diagnostic criteria, the overall prevalence of hyperuricemia among the participants was 9.9%, with 8.9% in males and 10.7% in females. Male participants were more likely to have higher SUA levels compared to females
Conclusion: This study reveals a significant correlation between serum uric acid (SUA) levels and lipid profile in the adult population. It emphasizes the importance of early intervention to prevent hyperuricemia and dyslipidemia in order to reduce the occurrence of cardiovascular disease in adults
Key Words: Serum uric acid, Lipid Profile