18. Thyroid Dysfunction in Women with Primary Subfertility
Sadia Saeed1, Wadiat Khan2, Abida Rasheed3, Sadia Nazir1, Uzma Shaheen2 and
Asia Fayaz2
ABSTRACT
Objective: Calculate and determine the frequency and thyroid dysfunction pattern in women having primary subfertility.
Study Design: Descriptive / Cross sectional study.
Place and Duration of Study: This study was conducted at the outdoor of Gynaecology and Obstetrics department, DG Khan Medical College and Nishtar Hospital, Multan from May 2015 to November 2015.
Materials and Methods: Final approval of investigation was taken by the ethical board of the hospitals. Sampling was done by non-probability consecutive sampling. A 5 cc sample of venous blood was drawn and sent to laboratory evaluation of serum T3, T4 and TSH levels. Version 22 of SPSS was used to analyze the data. Quantitative variables such as age (in years), duration of marriage, BMI, serum T3, T4 and TSH value analyzed in means and standard deviations. Qualitative variables i.e. thyroid dysfunction pattern (hypothyroidism, hyperthyroidism) was calculated in percentage. The effect modifiers like age, BMI and time span of marriage were controlled through stratification. To see the outcome, chi square test was applied after stratification. P value of less or equal to 0.05 was significant for this study.
Results: Total 250 patients were taken in this project. The mean age, duration of marriage, BMI, serum T3, serum T4 and TSH of the patients was 30.38±3.54 years, 4.53±2.22 years, 27.72±3.25 Kg/m2, 1.82±1.13 ng/ml, 6.39±2.49 ug/dl and 3.90±2.03uIU/ml, respectively. The outcome variables of our study was hypothyroidism and hyperthyroidism. It was seen in n=73 (29.2%) and n=23 (7.6%) patients, respectively. (Table. 2). No association was found between age, duration of marriage and BMI with hypothyroidism and hyperthyroidism.
Conclusion: Conclusion of this project was that hypothyroidism is one of the main and emerging reasons of primary infertility. Proper management of hypothyroidism can result in regain of fertility. Assessment and screening of thyroid status should be part of criteria in infertile patients.
Key Words: Primary subfertility, Hyperthyroidism, Hypothyroidism
Citation of article: Saeed S, Khan W, Rasheed A, Nazir S, Shaheen U, Fayaz A. Thyroid Dysfunction in Women with Primary Subfertility. Med Forum 2021;32(3):77-81.