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Uzma Gul¹, Syed Furqan Ahmad Hashmi¹, Shazia Kadri¹ and Mubarika Anwari²

ABSTRACT

Objective: To determine treatment related toxicity in gynecological malignancies after conventional radiotherapy.

Study Design: Descriptive study

Place and Duration of Study: This study was conducted at the Department of Radiation Oncology, Atomic Energy Medical Centre, Jinnah Post Graduate Medical Centre, Karachi from January 2017 to December 2018.

Materials and Methods: The study includes Patients who received chemotherapy, assessed before commencement of radiotherapy, during and at the end of treatment for frequency and severity of sides effects and evaluated according to toxicity proforma, based on RTOG/EORTC and CTC version 4 criteria.

Results: Total 97 patients with mean age 48.55±8.44 years. The adjunctive treatment was given to 57patients and definitive treatment to 40 patients. The results of comparison of gastrointestinal and urinary toxicity with age and marital status showing statistically significant difference between the nausea condition with age. i.e p-value=0.001 and between the nausea condition with marital status of the patients i. e p-value=0.025. Comparison of gastrointestinal and urinary toxicity with stages of cancer showing p-value=0.370, 0.144, 0.969 & 0.863 respectively. Statistically significant difference between the Proctitis with stages of cancer i.e. p-value=0.007. Dermatological and hematological toxicity with chemotherapy showing statistically significant difference between the chemotherapy with neutropenic patients i.e p-value=0.011.

Conclusion: Study concluded that nausea is associated with age and marital status however neutropenia is more prevalent in patients received chemotherapy. Women with advanced gynecological cancers receiving radiotherapy are more prone to develop proctitis than early stage gynecological cancers interestingly stage of cancer is not associated with dermatological and hematological toxicity.

Key Words: Gynecological cancer, Pelvic Radiotherapy, Gastrointestinal

Citation of article: Gul U, Hashmi SFA, Kadri S, Anwari M. Treatment Related Toxicity in Gynecological Malignancies after Conventional Radiotherapy. Med Forum 2023;34(3):75-79.