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17.Association of Urinary Prostaglandins with Uric Acid in Hyperuricemia Patients
Sikander Afzal1, Muhammad Haroon Ghous2 and Mahwish Arooj2
ABSTRACT
Objective: The main objective of the study is to find the association of urinary prostaglandins with uric acid in hyperuricemia patients.
Study Design: A Retrospective Observational Study
Place and Duration of Study: This study was conducted at the University of Lahore Teaching Hospital from January 2016 to December 2022.
Materials and Methods: Data collection involved retrieving relevant information from medical records, including patient demographics, medical history, and laboratory results. Serum uric acid levels were recorded for each patient, and urinary sample were collected for prostaglandin analysis.
Results: Data was collected from 200 patients of both genders. Mean age of the patients included in the study was 54.8±6.2 years. Out of the 200 hyperuricemia patients, 120 were male, and 80 were female. The average duration of hyperuricemia diagnosis was 3.7±2.1 years. The mean baseline serum uric acid level in the cohort was 8.5±1.2 mg/dL. Male participants exhibited higher mean uric acid levels (9.2±1.3mg/dL) compared to females (7.8±1.0 mg/dL).
Conclusion: It is concluded that urinary prostaglandins, particularly PGE2 and PGI2, are associated with serum uric acid levels in hyperuricemia patients. These results highlight the potential roles of prostaglandins in uric acid metabolism and may have implications for personalized therapeutic interventions in managing hyperuricemia and its associated complications.
Key Words: Uric Acid, Patients, Prostaglandins, Efficacy