17. Entering the Post-Antibiotic Era: A Review of 200 Cultures from a Tertiary Care Hospital in Lahore
Aneela Chaudhary1, Muhammad Asim Rana1, Dawar Ayyaz2 and Khalid Waheed3
ABSTRACT
Objective: To analyse the spectrum of resistance of various pathogens against commonly used antibiotic in a tertiary care hospital, Lahore.
Study Design: Retrospective study
Place and Duration of Study: This study was conducted at the Lahore General Hospital from January 2017 to April 2018.
Materials and Methods: A total of 200 culture reports, sent from medical and surgical departments including ICUs of the hospital. Cultures of sputum, tracheal secretions, blood, pleural fluid, urine and tip of urinary catheter and CVP line were included.
Results: Out of 200 positive cultures, the majority (70%) were of respiratory tract origin. Gram negative bacteria prevailed (92%) as compared to gram positive pathogens which were just (8%). E coli (22%) and Pseudomonas (22%) were the commonest bugs followed by Klebsiella (17%) and Acinetobacter (17%). All gram-negative isolates showed very high rates of resistance against 3rd generation cephalosporins, amoxiclav, ciprofloxacin and gentamycin. Alarming levels of carbapenem resistance was documented in Acinetobacter (55.9%) and Klebsiella (51%) isolates. Ecoli (22%) and pseudomonas (31%) were relatively less resistant to carbapenems. MRSA accounted for 62.5% of staphylococcal samples.
Conclusion: The rapid and exponential rise in antimicrobial resistance is a serious threat for patient in the 21st century. It has reached alarming levels in different parts of world. There is an urgent need to develop and enforce strict controls on antibiotic usage.
Key Words: Antibiotic resistance, culture, pathogens, Bacterial resistance
Citation of articles: Chaudhary A, Rana MA, Ayyaz D, Waheed K. Entering the Post-Antibiotic Era: A review of 200 Cultures from a Tertiary Care Hospital in Lahore. Med Forum 2019;20(1):68-72.