16. A Comparative Observational Study Signifying the Diversity of Clinical Features in Patients having Tuberculosis with and Without Renal Failure
Mahnoor Khalil1, Syed Muhammad Baquar Raza1, Ajmaal Jami3, Syed Mubarak Ali2, Yumna Ahmed1 and Siraj Us Salkeen1
ABSTRACT
Objective: Renal failure has in recent period exposed a shocking augmentation globally and there are increasing facts demonstrating that it can affect presentation and results of treatment in patient of TB disease. This study was performed to study the differences in presentation of pulmonary tuberculosis in patients who present with renal failure and who present without renal failure.
Study Design: Comparative Observational Study
Place and Duration of Study: This study was conducted at the Dept. of Medicine, Abbasi Shaheed Hospital, Karachi from May 2018 to September 2019.
Materials and Methods: The study comprised of a total of 107 patients. All the patients who were diagnosed cases of pulmonary tuberculosis were chosen for this study and on the basis of the data patients were allotted to two groups. The patients of tuberculosis who were found to have renal failure were kept in Group one and other group had patients of tuberculosis without renal failure. Data was analyzed using SPSS version 20.0. Quantitative data was presented as mean ± SD while qualitative was presented as frequency (%). T-test and chi- square test were used to assess the significance and p-value was set at 0.05.
Results: In a total of 107 patients 62 (58%) were males and 45(42%) were females divided into 2 groups. The mean age of patients was 64.56±8.77 years in renal failure group and 38.25±12.70 years in without renal failure group. Substantial differences were observed between the 2 groups with respect to not only the laboratory values such as lymphocytes, neutrophils and protein but also with regards the clinical features (p<0.001).
Conclusion: The present study concluded that a significant difference existed regarding the clinical indices of TB patients with renal failure and without renal failure in the patients. The features including shortness of breath, productive cough, chest pain, hemoptysis, pleural effusion and diabetes mellitus were observed to be more common in renal failure group while night sweats, fever, and fatigue were more common in the non-renal failure group.
Key Words: Pulmonary Tuberculosis, renal failure, non-renal failure.
Citation of article: Khalil M, Raza SMB, Jami A, Ali SM, Ahmed Y, Salkeen S. A Comparative Observational Study Signifying the Diversity of Clinical Features in Patients having Tuberculosis with and Without Renal Failure. Med Forum 2020;31(10):70-74.