15.Comparison of Efficacy of Intralesional 5-Fluorouracil Plus Triamcinolone Versus Triamcinolone Alone in the Treatment of Keloids
Seemab Khan, Muhammad Usman and Tooba Malik
ABSTRACT
Objective: To compare the efficacy of triamcinolone acetonide (TAC) alone versus triamcinolone plus 5-fluorouracil (5-FU) in patients with keloids in terms of the proportion of patients who improved significantly.
Study Design: A Randomized controlled study
Place and Duration of Study: This study was conducted at the Department of Dermatology/Plastic Surgery, Bakhtawar Amin Teaching Hospital Multan from 18th March 2019 to 18th March 2020.
Materials and Methods: We enrolled 160 patients at the Bakhtawar Amin Teaching Hospital and randomly assigned them to receive Intralesional triamcinolone (group 1) or a combination of TAC and 5-fluorouracil (5-FU) for one year (group 2).
Results: The average age at the time of the survey was 30.748.47 years. There were no statistically significant variations between the two groups in terms of age and gender distribution in this study. Males made up 40% of the group, while women made up the rest (a 25 % male to female ratio). Only 16% of the TAC patients responded to treatment, but 75% of the 5-FU + TAC patients responded. There was a statistically significant difference between the two groups, and this was confirmed by a p value of 0.05.
Conclusion: The efficacy in terms of frequency of patients with good to outstanding improvement in keloids was significantly greater in triamcinolone + 5-FU group as compared to the triamcinolone alone group.
Key Words: Intralesional triamcinolone, Keloids, Hypertrophic scars, Triamcinolone acetate, 5- Fluorouracil
Citation of article: Khan S, Usman M, Malik T. Comparison of Efficacy of Intralesional 5-Fluorouracil Plus Triamcinolone Versus Triamcinolone Alone in the Treatment of Keloids. Med Forum 2022;33(5):62-66.