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  3. 15. Prediction of Pregnancy-Induced Hypertension by Maternal Beta-hCG Levels in the Mid-Trimester of Pregnancy
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15. Prediction of Pregnancy-Induced Hypertension by Maternal Beta-hCG Levels in the Mid-Trimester of Pregnancy

Original Article

 

Prediction of Pregnancy-Induced Hypertension

Prediction of Pregnancy-Induced Hypertension by Maternal Beta-hCG Levels in the Mid-Trimester of Pregnancy

Hafiza Nida Mumtaz1, Saima Ahmed1, Asma Hameed1, Sadaf Ali2 and Kiran Kalsoom2

ABSTRACT

Objective: The study objective was to evaluate the association between mid-trimester Beta-hCG levels and the risk of PIH to assess its potential as a predictive marker.

Study Design: Prospective, observational study

Place and Duration of Study: This study was conducted at the Gynae and Obstet Department, Swat Medical College, Swat and Saidu Group of Teaching Hospitals, Swat from June 2022 to June 2023.

Methods: The study conducted on 130 pregnant women, divided into two groups: 65 with PIH and 65 Non PIH. Beta-hCG levels were measured between 13 and 20 weeks of gestation age. Demographic and clinical data, blood pressure (BP), BMI, family history of hypertension, and smoking status, were collected. ‘Statistical analyses were performed with chi-square tests, independent t-tests, logistic regression, and ROC curve analysis to determine the predictive value of Beta-hCG’.

Results: The study revealed, no significant association was observed between Beta-hCG quartiles and PIH incidence. Whereas the ‘ROC analysis showed an area under the curve (AUC)’ of 0.524, indicating minimal ‘predictive’ ability, other factors, BMI, family history of hypertension, and smoking status had significant associations with PIH.

Conclusion: Only ‘Beta-hCG levels’ were not sufficient as an individual marker for PIH risk. The study suggests that a multifactorial approach, including both biomarkers and clinical factors, may provide accurate assessment for PIH risk. Further research is needed for comprehensive predictive models for PIH screening, particularly in resource-limited settings.

Key Words: Pregnancy-induced hypertension, Beta-hCG, predictive markers, maternal health

Citation of article: Mumtaz HN, Ahmed S, Hameed A, Ali S, Kalsoom K. Prediction of Pregnancy-Induced Hypertension by Maternal Beta-hCG Levels in the Mid-Trimester of Pregnancy. Med Forum 2024;35(10):
63-68. doi:10.60110/medforum.351015.