14.To Elucidate the Decrement of Testicular Weights After Oral Doses of Lithium Carbonate in Albino Rats
Tazeen Kohari1, Meshaal Azhar2, Faryal Azhar2 and Usama Faruqui3
ABSTRACT
Objective: To find out the effects of Lithium carbonate on the testes weights in Control group and the treated group with Lithium carbonate of albino rats.
Study Design: Experimental study
Place and Duration of Study: This study was conducted at the Department of Anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, from 30th June till July 2013.
Materials and Methods: Forty male adult albino rats of three months of age were chosen for this study and distributed into two equal groups A, B. They were, treated for six weeks .Group A served as control received laboratory oral diet, group B received lithium Caronate orally in flour pellets at a dose of 34 mg/kg body weight. For six weeks. At the end of treatment testes weights were recorded in both groups.
Results: The rodents were weighed on digital weighing balance at the start and end of the study. The body weights were recorded and compared. The Body weight of Albino rats of group A were highly significantly increased as compared to Group B. The mean values of weights of testes were highly significantly decreased in B, when comparing with group-A. The values of weights of testes in groups A were highly significantly increased when compared with group B. These findings showed that Lithium induced testicular toxicity due to reduction in testes weights.
Conclusion: One of the many harmful adverse effects of lithium is its reduction of testicular weights in albino rats.
Key Words: Elucidate, Decrement, Testes. Reproductive toxicity
Citation of article: Kohari T, Azhar M, Azhar F, Faruqui U. To Elucidate the Decrement of Testicular Weights After Oral Doses of Lithium Carbonate in Albino Rats. Med Forum 2021;32(11):60-62.