14. To Measure the Synergistic Effects of Aloe Vera and Rosiglitazone on Blood Glucose, Insulin and Insulin Resistance in Stretozotocin Induced Diabetic Rats
Meena Gul1, Aysha Babar2, Mir Attaullah Khan3, Hoor Fawad Khan4 and Ziad Hamayun4
ABSTRACT
Objective: To measure the synergistic effects of Aloe vera and Rosiglitazone on blood glucose, insulin and insulin insensitivity in non-insulin dependent diabetes mellitus.
Study Design: Randomized control trail study
Place and Duration of Study: This study was conducted at Army Medical College, Rawalpindi in the Physiology Department from January 2009 to September, 2010 in alliance with National Institute of Health (NIH) Islamabad
Materials and Methods: Thirty healthy rats were made diabetic according to Srinivasan model. After confirming type 2 diabetes in them they were randomly segregated into two equal groups. The groups named diabetic were injected with normal saline and other combined group were given 150mg/kg body weight of Aloe vera extract and 2.5mg/kg body weight of rosiglitazone diabetic group. It was half their effective dose as their effective dose was calculated through pilot study.
Results: Plasma glucose, insulin, and TG/HDL ratio were significantly reduced (p<0.0000001) in combined group then diabetic control group
Conclusion: The significant result was obtained in combined group in lowering plasma glucose, insulin and insulin resistance though half their effective doses were used. It will also help in reducing side effects associated with use of rosiglitazone.
Key Words: Aloe vera, rosiglitazone, T2DM, insulin
Citation of article: Gul M, Babar A, Khan MA, Khan HF, Hamayun Z. To Measure the Synergistic Effects of Aloe Vera and Rosiglitazone on Blood Glucose, Insulin and Insulin Resistance in Stretozotocin Induced Diabetic Rats. Med Forum 2016;27(10):53-56.