Become A Member

Study of Biochemical Changes in Children with Autism Spectrum Disorder Aged 3-13 Years in Thi-Qarcetnter of Autism

Naeem Salih Yaser¹, Maha Fadhil Smaism¹ and Rebee Mohsin Hasani²

ABSTRACT

Objective: To find out the causes of autism spectrum disorder therefore some biochemical parameters were measured include serum lactate, pyruvate, lactate to pyruvate ratio, lactate dehydrogenase, ferritin and glutamate.

Study Design: Case-control study

Place and Duration of Study: This study was conducted at the Thi-Qar Autistic Center, Nasiriya City, Iraq from
1^st September 2022 to 28^th February 2023.

Methods: This study contained 192 children among which 96 patients were diagnosed as cases of ASD and age range was 3 to 13 years. The control group contained 96 children with ages range was 3-13 years. The Enzyme Linked Immunosorbent Assay method is applied in detection of parameters.

Results: there were significant statistical association between biochemical parameters and autism spectrum disorder in compare with control group except serum pyruvate in which there was no significant association

Conclusion: The cause of autisms spectrum disorder may be a defect in mitochondrial functions where there was elevation in serum lactate and lactate to pyruvate ratio.

Key Words: Autism spectrum disorder, Lactate, Pyruvate, Lactate dehydrogenase, Ferritin

Citation of article: Yaser NS, Smaism MF, Hasani RM. Study of Biochemical Changes in Children with Autism Spectrum Disorder Aged 3-13 Years in Thi-Qarcetnter of Autism. Med Forum 2025;36(1):67-71. doi:10.60110/medforum.360114.