14. Diagnostic Utility of Bone Marrow Examination in Patients with Splenomegaly Referred For Hematological Evaluation
Mariam Riaz1, Iffat Naiyar2, Uzma Faryal3 and Madood-ul-Mannan1
Objective: To see the diagnostic utility of bone marrow examination in patients with splenomegaly that require hematological workup.
Study Design: Cross sectional study.
Place and Duration of Study: This study was conducted at the Department of Pathology, Women Medical College, Abbottabad from Jan 2013 to Dec 2015.
Materials and Methods: Patients of both gender and all age groups with palpable spleen referred for hematological workup. Cases with haemolytic anemia were subjected to relevant investigations and excluded from the study. The patients underwent clinical evaluation & hematological investigations. These included peripheral blood smear, reticulocyte count, automated cell counts by cell counter and bone marrow aspiration or biopsy
Results: 80 patients were received. 47 were adults and 33 patients were of pediatric age group. In the adults anemias were seen in 38.2%, hematological malignancies in 27.6%, infective disorder in 17%, congestive splenomegaly in 10.6 % and chronic granulomatous disease in 2%.
In children, hematological evaluation revealed hematological malignancies in 33.3%, visceral leishmaniasis in 21.2%, nutritional anemias 18%, storage disorder in 9%, malarial parasite in bone marrow in 6% and congenital sideroblastic anemia in 3%. Five cases remained undetermined in both groups. Hypersplenism was observed in 21% adults and 27%pediatric patients with splenomegaly
Conclusion: Bone marrow examination is the key investigation to evaluate etiology of splenomegaly. Hematological malignancies constituted 27.6 % of the adult and 33.3% of pediatric age group patients.
Hypersplenism was observed in about one fourth of patients with splenomegaly.
Key Words: Splenomegaly. Bone marrow examination. Malignancy. Hypersplenism
Citation of article: Riaz M, Naiyar I, Faryal U, Mannan M. Diagnostic Utility of Bone Marrow Examination in Patients with Splenomegaly Referred For Hematological Evaluation. Med Forum 2017;28(1):56-60.