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13.Fosfomycin an Old Drug with A New Role in E.Coli Associated Urinary Tract Infections

Shandana Altaf1, Ahmad Zeb Khan2, Farman Ullah2, Irfan Mirza2, Sayed Anwar Hussain3 and Mufti Baleegh-ur-raheem Mahmood2

ABSTRACT

Objective: To know the impact of Fosfomycin an Old Drug with A New Role in E.Coli Associated Urinary Tract Infections.

Study Design: Descriptive Study

Place and Duration of Study: This study was conducted at the department of Nephrology Khyber Teaching Hospital, Peshawar from July 2020 to June 2021 for a period of one year.

Materials and Methods: Urine Culture Sensitivity of patients with UTI was assessed and E. Coli sensitivity pattern was studied.

Results: Over all sensitivity of E. coli to Fosfomycin was 84.31% in the studied population. According to gender distribution of the cohort the sensitivity to Fosfomycin was 83.33% in male patients and 84.84% in the female patients. To compare the sensitivity of Fosfomycin versus other antibiotics in UTI, we found that Fosfomycin was showing sensitivity against E. coli related UTI of 84.31% compared to that Ciprofloxacin 20.58%, Trimethoprim sulphamethoxazole 17.64% and Amoxicillin-clavulanic acid 13.72%.

Conclusion: This study shows that in the presence of mounting antibiotics resistance, Fosfomycin is a safe and suitable alternative in the treatment of UTI caused by MDR pathogens like E. Coli which otherwise do not  respond to other antibiotics.

Key Words: UTI, E. Coli, Fosfomycin

Citation of article: Altaf S, Khan AZ, Farman Ullah, Mirza I, Hussain SA, Mahmood MB. Fosfomycin an Old Drug with A New Role in E.Coli Associated Urinary Tract Infections. Med Forum 2021;32(12):55-59.