Naeem Ul Haq¹, Akram Ullah², Syed Nasir Shah¹ and Inayat Shah¹

ABSTRACT

Objective: To find the comparative pass survival and/or GBM resections, cognitive feature preservation, along with BMC complication rates.

Study Design: A cross-sectional study

Place and Duration of Study: This study was conducted at the Department of Neurosurgery MMC Mardan from Jan 2024 to July 2024.

Methods: A total of 120 patients with GBM underwent surgery between 2015 and 2023, and records of these patients were reviewed in a multicenter study retrospectively. The assessment of GTR and STR results was performed. Measures used were progression free Survival, Complication rates and Health related quality of life. Data normality was computed using Shapiro Will test and further analyzed using standard deviation and p-value where p<0.05 was used as a criterion for statistical significance.

Results: Of 120 patients, GTR was possible with 70%, the median survival time increasing to 18.5 ±2.3 months, p < 0.01). STR was carried in 30%, of these patients the median survival was calculated to be 10.2 months ± 1.8 & p < 0.05. Specific postoperative neurosurgical morbidity included new neurological deficit (25%), infection (7 %), and leakage of CSF (5%). According to the measures we employed, there was a significant enhancement of quality of life in the GTR patients.

Conclusion: Safe surgical removal can enhance survival in patients with GBM and GTR has better results than STR. A lot of attention and the use of modern technologies allow avoiding complications. The recurrence rates still high and call for more studies of the additional treatment.

Key Words: Glioblastoma, surgery, prognosis, risks