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13. Study of Biochemical, Hematological & Clinical Profile of Dengue Fever Patients in a Tertiary Care Hospital in Northern Pakistan

Mohsin Shafi1, Syed Shahmeer Raza3, Zarmina Hussain1, Fatima5 and Syed
Muhammad Owais4

ABSTRACT

Objective: To assess the changes in biochemical and hematological profiles of the patients with dengue and to evaluate the effects of the patient’s co-morbidities on the outcome.

Study Design: Descriptive / observational and retrospective study

Place and Duration of Study: This study was conducted at the Medical Ward of Hayatabad Medical Complex, Peshawar from August 2017 to October 2017.

Materials and Methods: This study was carried on a total of 470 patients. Biochemical tests namely ALT, AST and Creatinine along with full blood count were carried out. SPSS 20 was used for statistical analysis.

Results: Biochemical markers such as AST and ALT showed a wide degree of deviation from the mean while platelets and WBC counts were markedly decreased. Fever, Headache and Myalgia was the most common presenting complaints whereas Capillary leak, Acute Respiratory Distress Syndrome and Multi organ failure were the major complications. Diabetes mellitus, malaria and coronary artery disease were reported to be the major co-morbidities.

Conclusion: Dengue is a matter of global health concern and has become increasingly hard to manage and control over the last decade. It is a public health care issue and needs to be addressed in due time. Moreover, our study highlights the importance of admission and timely management of dengue patients with comorbid, which are lethal if not managed properly. So routine biochemical tests should be carried out to rule out these.

Key Words: Dengue; Pleural Effusion; Capillary leak; Epidemic

Citation of articles: Shafi M, Raza SS, Hussain Z, Fatima, Owais SM. Study of Biochemical, Hematological & Clinical Profile of Dengue Fever Patients in a Tertiary Care Hospital in Northern Pakistan. Med Forum 2019;30(5):52-55.