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12.Antibiogram Pattern of Urinary Tract Infections

Muhammad Tayyab Naeem1, Abdul Rauf1, Fazal-ur-Rehman Khan1, Hammad Shafi2, Saba Rasool3 and Zeeshan Shaukat4

ABSTRACT

Objective: To determine the susceptibility pattern of three most common uropathogens; E. Coli, Enterococci sp and Klebsiella sp.

Study Design: A cross-sectional study

Place and Duration of Study: This study was conducted at the Department of Urology, National Institute of Kidney Diseases, Shaikh Zayed Hospital, Lahore from 1st March to 30th June 2021.

Materials and Methods: One hundred and thirty patients were selected with confirmed UTI symptoms. Early morning mid-stream urine was collected in sterile wide mouth containers and exposed to CLED (a differential media) to get pure growth. The isolated microbes were subjected to Kirby-Bauer disk diffusion method to obtain antibiotic susceptibility pattern of each uropathogen. Muller Hilton agar plate was used to receive susceptibility pattern to test antibiotics. Uropathogens were declared sensitive, intermediate or resistant by using CLSI.

Results: E.coli, Enterococci sp and Klebsiella sp were found 46.20%, 33.10% and 21.70%, respectively in 130 clinically verified UTI patients. Escherichia Coli showed 90% sensitivity to Colistin and 86.70% to Nitrofurantoin. Whereas, Enterococci sp manifest 100% sensitivity to Linezolid, Teicoplanin and Gentamycin. Klebsiella sp exhibited maximum sensitivity to Aminoglycosides group (Amikacin 92.6% and Gentamycin, 92.6%).

Conclusion: E. coli was the most common pathogen in the urine of the UTI patients. Irrational consumption of antibiotics is increasing and the pipeline to develop new antibiotics is dry. Antibiotics should be used rationally in clinical setups employing locally designed antibiogram patterns.

Key Words: Antibiogram, Uropathogens, Antibiotics, Culture

Citation of article: Naeem MT, Rauf A, Khan FR, Shafi H, Rasool S, Shaukat Z. Antibiogram Pattern of Urinary Tract Infections. Med Forum 2022;33(3):49-52.