Search Submit Your Manuscript

Become A Member

  1. Home
  2. January 2023
  3. 11.Synthesis & Evaluation of Drug Release from Amoxicillin Loaded Chitosan Nanoparticles Incorporated in the Periodontal Membranes
Article Image
Admin

11.Synthesis & Evaluation of Drug Release from Amoxicillin Loaded Chitosan Nanoparticles Incorporated in the Periodontal Membranes

Nausheen Ashraf1, Isra Rana2, Maryam Saeedullah1 and Bakhtawar Yaqoob3

ABSTRACT

Objective: (1) To fabricate Amoxicillin loaded chitosan nanoparticles and evaluate them for their morphology, size and drug releasing profile. (2) To incorporate these nanoparticles in the fabricated periodontal membranes and evaluate their pattern of drug release.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at the Study was conducted at RIPS (Riphah Institute of Pharmaceutical Sciences) Islamabad in collaboration with IST (Institute of Space and Technology) and Quaid e Azam University Islamabad from April 2020 to February 2021 for a duration of ten months.

Materials and Methods: Amoxicillin loaded chitosan nanoparticles were fabricated by ionic gelation method and were characterized by using SEM and Zeta sizer. The pattern of the drug release was observed over a period of 24 hours by using dissolution apparatus. These nanoparticles were incorporated in the fabricated membranes and the pattern of drug release from the membranes was also observed.

Results: Amoxicillin loaded nanoparticles displayed spherical shape with a uniform size of 150.6±2.5 nm and depicted an initial burst followed by a sustained drug release pattern. An initial burst release of the drug followed by a slow and sustained pattern of amoxicillin was also observed from the membranes until 24 hours.

Conclusion: It can be suggested from the results that the fabricated Amoxicillin nanoparticles can serve as effective carriers for the drug. Also, the fabricated membranes incorporated with drug loaded nanoparticles show their potential to be used in the periodontal therapy possessing controlled drug release feature.

Key Words: Amoxicillin loaded nanoparticles, Chitosan, Dissolution apparatus, Lyophilization, Sustained drug release

Citation of article: Ashraf N, Rana I, Saeedullah M, Yaqoob B. Synthesis & Evaluation of Drug Release from Amoxicillin Loaded Chitosan Nanoparticles Incorporated in the Periodontal Membranes. Med Forum 2023;34(1):47-51.