11. The Role of C – Reactive Proteins as Indicator of Antibiotic Therapy among Patients with Acute Exacerbation of Chronic Obstructed Pulmonary Disease
Muhammad Mujtaba Ali1, Rashid Ali2 and Hafiz Muhammad Taha Waqas3
ABSTRACT
Objective: This study was conducted to define role of CRP as indicator of antibiotic therapy among patients with COPD.
Study Design: Descriptive case series Study
Place and Duration of Study: This study was conducted at the Department of Pulmonology, Shalamar Medical and Dental College Lahore from June, 2019 to January, 2020.
Materials and Methods: The study included 100 cases fulfilling inclusion criteria. Serum CRP levels were measured in all patients and were categorized as: low CRP (<40 mg/L) and high CRP (>40 mg/L). Patients in both groups received antibiotic therapy (Levofloxacin 500mg twice daily per oral) for 7 days. Patients were assessed for clinical success (absence of dyspnea and sputum).
Results: High CRP level was observed in 65(65%) patients and low in 35(35%) patients. Clinical success was achieved among 14(40%) patients in low CRP group and 56(86.2%) patients with high CRP group (p<0.05).
Conclusion: Majority of patients had high CRP level (>40mg/L). So, CRP level can be used as an indicator for commencement of antibiotic therapy among patients with acute exacerbation of COPD. Key Words: Chronic obstructive pulmonary disease; C–reactive Proteins; antibiotic therapy
Citation of article: Ali MM, Ali R. Waqas HMT. The Role of C – Reactive Proteins as Indicator of Antibiotic Therapy Among Patients with Acute Exacerbation of Chronic Obstructed Pulmonary Disease. Med Forum 2020;31(12):49-52.