1. Meena Gul 2. Rizwan Faisal 3. Shams ur Rehman

1. Asstt. Prof. of Physiology, GKMC, Swabi 2. Assoc. Prof. of Pharmacology, RMI, Peshawar 3. Assoc. Prof. of Medicine, GKMC, Swabi

ABSTRACT

Objective: To determine the effect of Aloe vera whole leaf extract and/or Rosiglitazone on plasma glucose, insulin and insulin resistance in type 2 diabetic Sprague-Dawley rats.

Study Design: Randomized control trail

Place and Duration of Study: This study was conducted at the Department of Physiology Army Medical College, Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad from April 2009 to Oct 2010.  Materials and Methods: Type 2 DM was induced in 45 healthy Sprague –Dawley rats by feeding high fat diet for 2 weeks and injecting a low dose (35mg/kg) of streptozotocin intra peritoneally. Type 2 diabetic rats were randomly divided into three groups, each group having 15 rats and were labeled as diabetic group, Aloe vera group and rosiglitazone group. The diabetic group was injected normal saline, Aloe vera group was treated with Aloe vera whole leaf extract in dose of 300mg/kg body weight and rosiglitazone group was given 5mg/kg body weight of rosiglitazone I/P for 21 days.

Results: A significant reduction (p<0.001) in plasma glucose (62%), insulin (19%) and TG/HDL ratio (69%) was analyzed in Aloe Vera group as compared to diabetic control group. 

Conclusion:  The maximum impact in lowering plasma glucose, insulin and TG/HDL ratio was recorded in rosiglitazone group, followed by Aloe vera group. The results of present study provide a scientific basis of using Aloe vera whole leaf extract as antidiabetic in T2DM.       

Key Words: T2DM. Aloe vera, Hyperinsulinemia, Insulin Resistance

Citation of article: Gul M, Faisal R, Rehman S. Effect of Aloe Vera Whole Leaf Extract on Blood Glucose,

Hyperinsulinemia and Insulin Resistance in Streptozotocin Induced Type 2 Diabetic Rats. Med Forum 2015;