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Subhan Shahid, Muhammad Abubakar, Azeem Iqbal, Tasawar Abbas,
Muhammad Zain-ul-Abidin

ABSTRACT

Objective: To determine role of diacerein among the patient with primary osteoarthritis knee.

Study Design: cross sectional study

Place and Duration of Study: This study was conducted at the department of orthopedic surgery Sir Ram Hospital Lahore. Study was completed in six months duration from July, 2021 to December, 2021 for a period of six months.

Materials and Methods: Patients presenting to the out-patient department with primary osteoarthritis knee having age >50 years were included in this study. Patients were evaluated according to WOMAC (Western Ontario and McMaster Universities Arthritis Index) and VAS (visual analogue Scale). Patients were given diacerein 100mg twice daily for 06 months duration. WOMAC and VAS were recorded of study patients initially and after six months and results were compared to see improvement in the patients.

Results: There were 110 cases in this study including 60(54.5%) male and 50(45.5%) female cases. All patients were having age >50 years with mean age of 59.28 ± 4.64 years. Before and after treatment mean WOMAC score was 46.34 ± 5.72 and 35.92 ± 16.4 respectively (p<0.05) while mean VAS was 6.43 ± 2.50 and 4.4 ± 1.22 respectively (p<0.05). 30% improvement was seen in 45% cases. Efficacy of the drug was labelled as yes in 45% cases. Only two patients suffered from diarrhea while one patient had deranged LFTs after treatment.

Conclusion: Patients showed significant improvement in the mean WOMAC and VAS scores after six months therapy of diacerein. This drug can be considered as an alternative therapy among those patient who don’t respond to conventional analgesics therapy.

Key Words: Diacerein, improvement, Osteoarthritis Knee, VAS, WOMAC

Citation of article: Shahid S, Abubakar M, Iqbal A, Abbas T, Zain-ul-Abidin M. Role of Diacerein in Primary Osteoarthritis Knee: A Cross Sectional Study Conducted in a Tertiary Care Hospital. Med Forum 2022;33(1):40-43.