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  3. 10.Eradication of Helicobacter Pylori Infection; The Efficacy of High Dose Vonoprazan and Amoxicillin Dual Therapy
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10.Eradication of Helicobacter Pylori Infection; The Efficacy of High Dose Vonoprazan and Amoxicillin Dual Therapy

Muhammad Abid Shah1, Salma Ayaz1, Nizamuddin1, Irum Mehmood1, Mahnoor Shah2 and Samiullah3

ABSTRACT

Objective: This study aims to determine the role of the novel drug vonoprazan base dual therapy in high doses for HP eradication in the Pakistani population.

Study Design: Descriptive-cohort study

Place and Duration of Study: This study was conducted at the Ethical Board Khushal Medical Center Peshawar from September 2022 to February 2023.

Methods: This descriptive cohort study includes 102 HP positive treatment naïve patients. All the patients were given vonoprazan 40mg OD and amoxicillin 1gm BD for 10 days. All the patients were followed for 3 weeks and then re-evaluated. The data were recorded on predesigned proforma and all the data were analyzed using SPSS version 22.0.

Results: In 102 participants, the mean age was 50.2±3.2 years while distribution of males to females was 36.3 and 63.7% respectively. Vonoprazan-based treatment completely eradicated H.P in 84.3% of patients while 15.7% of patients were non-responders. Gender and age does not influence the treatment outcome of the patients (p values >0.05).

Conclusion: High dose vonoprazan plus amoxicillin might be superior to other treatment regimens in the eradication of HP infections particularly in our vicinity.

Key Words: Amoxicillin, dual therapy, Helicobacter pylori infection, vonoprazan

Citation of article: Shah MA, Ayaz S, Nizamuddin, Mehmood I, Shah M, Samiullah. Eradication of Helicobacter Pylori Infection; The Efficacy of High Dose Vonoprazan and Amoxicillin Dual Therapy. Med Forum 2023;34(11):42-45. doi:10.60110/medforum.341110.