10.Anti-Oxident Effects of Cinnamon Extract in Alloxan-Induced Diabetic Rats
Raheela Adil1, Muhammad Sajid Khan1, Sabahat Gul4, Farheen Hameed2, Mohammad Sair2 and Muhammad Adnan Sadiq3
ABSTRACT
Objective: To evaluate the antioxidant effects of cinnamon extract in alloxan induced diabetic rats.
Study Design: Experimental Study
Place and Duration of Study: This study was conducted at the Al-Tibri Medical College Isra University Karachi Campus during the period of December, 2012 to June, 2013.
Materials and Methods: Experimental study was designed with total 32 numbers of male rats, and the animals were randomized selected from the animal house after taken an ethical approval from the concerned authority. Animals were divided into four groups on the therapeutic basis. Diabetes was induced in rats by using alloxan and the antioxidant effects were evaluated through antioxidant enzymes. The data was analyzed through SPSS by applying One-way ANOVA to compare the mean difference between the groups. The level of significance was considered P=<0.05.
Results: Antioxidant level was maintained among the diabetic rats after utilization of cinnamon extract.
Conclusion: The result indicates that in diabetic conditions, oxidative stress is induced that causes peroxidative damage to membrane lipids. Cinnamon extract helps in restoration of antioxidant enzyme activity and their transcription.
Key Words: alloxan-induced diabetes, oxidative stress, antioxidant enzymes, cinnamon
Citation of article: Adil R, Khan MS, Gul S, Hameed F, Sair M, Sadiq MA. Anti-Oxidant Effects of Cinnamon Extract in Alloxan-Induced Diabetic Rats. Med Forum 2021;32(7):39-42.