1. To See the Role of Metformin in Decreasing Hyperinsulinemia and Body Weight and Presentation of Poly Cystic Ovarian Disease
Razia Tariq Qureshi1, Asma Jabeen2 and Afra Rehman1
ABSTRACT
Objective: The objective of this study is to evaluate the role of metformin in decreasing hyperinsulinemia and body weight in our population and see the pattern of presentation of PCOD Study Design: Observational / Descriptive study.
Place and Duration of Study: This descriptive study was held in the Gynecology Department of Peoples University of Medical and Health Science, Nawabshah Pakistan from 2nd Jan 2013 to Nov 2014.
Materials and Methods: Overall 329 cases satisfying the inclusion criteria were incorporated in the study. Criteria for inclusion were founded upon presence on U/S with two or further of the given criteria like hyperandrogenism, hirsutism, and oligomenorrhea and proportion of reversed LH: FSH.
After receiving well-informed consent, demographic data and comprehensive history were recorded on self-created questionnaire. A comprehensive analysis was conducted. Relevant analyzes were made and metformin was initialized with a dosage of 250 milligram s.i.d. (1/day) in starting then step by step adjusted to 500-milligram t.i.d. (thrice/day) for six months. Weight loss was promoted through exercise and diet. Cases were evaluated later than 6 months to analyze their serum fasting insulin and change in BMI. Statistical analysis was carried out by SPSS V.17.0. P value less than 0.05 taken significant after applying the paired t test and Chi-square test.
Results: Total 335 women were included in the study, but six patients had l st follow-up. Complete data was available for 329 patients, which is evaluated. Most common presentation of these patients with PCOD was oligomenorrhea which is seen in 253 (76.89%) patients. Mean serum fasting insulin before treatment was 23.47 micro U/ ml. After six months treatment with metform n, t de reases to 20.78 micro U/ ml (P=<0.001) . Mean body weight before treatment was 69.4 kg and after treatment, t was 68.8kg (P= 0.6167) .
Conclusion: Metformin was a useful treatment in decreas g the level of insulin. Further large sample size studies are required.
Key Words: PCOD, metformin, insulin level
Citation of article: Qureshi RT, Jabeen A, Rehman A, To See the Role of Metformin in Decreasing Hyperinsulinemia and Body Weight and P esentati n of PCOD. Med Forum 2016;27(4):2-4.