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1. Pattern of Hematological Disorders in Abbottabad

1. Muhammad Usman Anjum 2. Syed Humayun Shah

1. Asstt. Prof. of Pathology, 2. Prof. of Pathology, Frontier Medical & Dental College, Abbottabad

ABSTRACT

Objective: To study the pattern of distribution of different hematological disorders in Abbottabad based on bone marrow examination results.

Study Design: Retrospective study.

Place and Duration of Study: This study was conducted at the Aksa Laboratory, Abbottabad from January 2011 to December 2013.

Materials and Methods: 143 patients, who presented to Aksa laboratory for bone marrow aspiration, were selected. Complete details of history, examination, blood tests were recorded. Bone marrow aspiration was performed using aseptic technique and bone marrow aspirate samples were prepared.

Results: Bone marrow aspirate results of 143 patients were studied. There were 104 cases (72.72%) of nonmalignant hematological disorders while 39 (27.27%) of hematological malignancies. Among non-malignant hematological disorders, megaloblastic anemia was the most common disease affecting 31 patients (29.80%), followed by iron deficiency anemia in 20 patients (19.23%). There were 39 cases (27.27%) of hematological malignancies. Out of these, 23 cases (58.97%) were of acute leukemia followed in descending order by 5 cases (12.82%) of multiple myeloma and 4 cases (10.25%) of chronic myeloid leukemia.

Conclusion: Megaloblastic anemia was the most common disease followed by iron deficiency anemia among nonmalignant hematological disorders. Acute leukemias were most common among malignant hematological disorders. Bone marrow aspiration was very useful in making a correct diagnosis and determining the cause of disease.

Key Words: Anemia, leukemia, malignant hematological disorders, non-malignant hematological disorders, bone

 

marrow aspiration.