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1. Assessment of Circulating Biochemical, Heamatological and Oxidative Stress Markers in Females Using Contraceptives from Punjab, Pakistan

1. Waheed Jamil Ch. 2. Muhammad Binyameen Chishti 3. Madiha Ashraf 4. Arif Malik 

5. Mahmood Husain Qazi

1. Asstt. Prof. of Physiology, AIMC, Lahore 2. Assoc. Prof. of Physiology, AIMC, Lahore 3. Asstt. Prof.

Physiology, AIMC, Lahore 4. Assoc. Prof. of Biochemistry, The University of Lahore 5. Director, Center for Research and Molecular Medicine, The University of Lahore

ABSTRACT

Objective: To Assess the circulating Biochemical, Heamatological and Oxidative Stress Markers in Females using Contraceptives from Punjab, Pakistan.

Study Design:  Case Control Study  

Place and Duration of Study: This study was carried out at the Gynae Units of Jinnah Hospital Lahore from January, 2011 to December 2011. 

Materials and Methods: Two injectable contraceptives (Depo-Medroxyprogesterone & NorethisteroneEnantate) and Oral contraceptive pills (COCs) were administered in females of reproductive age, the oxidative and nitrosative stress biomarkers (Malondialdehyde, Superoxide Dismutase, Catalase, Nitic oxide and Glutathione) were analyzed in these subjects.

Results: DMPA, NET-EN & COCs treatment could induce oxidative stress with a significant change in lipid profile and other biochemical markers thus affecting the normal biological system. These effects after prolonged use can generate pathological events leading to disease pattern.

Conclusion: These biomarkers can become diagnostic tools to evaluate the health of a woman using these methods as preventive measure in future

Key Words: Contraceptives, Estrogen, Progestin, Stress Biomarkers, Catalase, Glutathione, MDA, SOD