1. A Serum Level and Polymorphism of Interleukin -17 Gene (RS 8193036, RS 2275913) in Scabies Patients
Noora D. Abd1, Nagham Y. Albayati1 and Ali H. Abbas2
ABSTRACT
Objective: To assess how genotyping affects an individual's likelihood of developing scabies.
Study Design: Cross-sectional study.
Place and Duration of Study: This study was conducted at the Baquba Teaching Hospital- Consultation Clinic- Dermatology Unit/ Diyala Governorate from 4th of December, 2022 to 10th June, 2023.
Methods: Seventy-five male and female volunteer patients who clinically diagnosed with scabies and 75 non-infected individuals as a control were enrolled.
Results: There was an increase in IL-17 concentration of the patients' serum compared with control and there was genotype variation in both studied single nucleotide polymorphisms.
Conclusion: The serum level of IL-17 was increased in scabies group, the GA genotype and G allele of IL-17 SNPs rs 8193036 and the TT,CT genotypes and T allele of rs 2275913 were increased too with high OR value, the genotypes and alleles might be a risk factors from scabies infestation.
Key Words: Scabies, Genetic polymorphism, IL-17, Allele-specific, Serum levels
Citation of article: Noora D. Abd, Nagham Y. Albayati, Ali H. Abbas. A Serum Level and Polymorphism of Interleukin -17 Gene (RS 8193036, RS 2275913) in Scabies Patients. Med Forum 2024;35(7):3-8. doi:10.60110/medforum.350701.