9.Effect of Nigella Sativa on Platelets in Organophosphorus Induced Toxicity in Albino Rats
Muhammad Sajid Khan1, Raheela Adil1, Sabahat Gul4, Farheen Hameed2, Mohammad Sair2 and Muhammad Adnan Sadiq3
Objective: To evaluate the effect of Nigella Sativa on Platelets functions in Organophosphate induced toxicity
Study Design: Experimental Study
Place and Duration of Study: This study was conducted at the Al Tibri Medical College Isra University Karachi Campus from January 2015 to July 2015.
Materials and Methods: Thirty albino rats were selected through random sampling and divided into three groups. Group A was the control group, Group B the group that was induced with Chlorpyrifos, whereas Group C was the interventional group in which the Chlorpyrifos and Nigella Sativa was given. At the end of the experiment, the rats were sacrificed and blood samples were collected via cardiac puncture, after which Platelet count was assessed. Data was analyzed using SPSS. To compare the mean values one-way ANOVA, followed by Post Hoc Tukey’s test
Results: The mean platelet count of the groups were 185x103/m3 for Group A, 95x103/m3 for Group B, and 115x103/m3 for Group C. Significant difference was seen in the mean platelets count between Group A and B (P-value ≤0.01), and Group B and C (P-value ≤0.01). No significant difference was seen between Group A and C.
Conclusion: Nigella Sativa had a protective effect on Platelet count and hence function when Albino rats were subjected to Organophosphorus Poisoning.
Key Words: Nigella Sativa, Platelets, Organophosphorus Induced Toxicity, Albino Rats
Citation of article: Khan MS, Adil R, Gul S, Hameed F, Sair M, Sadiq MA. Effect of Nigella Sativa on Platelets in Organophosphorus Induced Toxicity in Albino Rats. Med Forum 2021;32(7):36-38.