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9. To Study the Efficacy of Racecadotril for Treatment of Acute Watery Diarrhea in Children

Nafees Khan1, Muhammad Qasim Khan1, Kiramat Ullah1, Muhammad Fazil1, Ammad Ali1 and Rifayat Ullah Afridi2

ABSTRACT

Objective: To study the efficacy of racecadotril on decreasing no of stools in pediatric population presenting with acute watery diarrhea to decrease the length of hospital stay.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at the Pediatric Unit MTI, Mardan Medical Complex from April to August 2019.

Materials and Methods: 120 children, aged 6 months to 2 years, were included and placed on random basis in a racecadotril or placebo group. Criteria of inclusion was patients diagnosed with acute gastroenteritis. Patient having any other disease or allergy were excluded. Racecadotril and placebo were given at a dose of 10 mg p/o TDS for children below 1 year, 30mg P/O TDS for children above 1 year. Data were collected and analyzed in SPSS 20.

Results: Mean age was 9.8 months. Females were 45.8% whereas males were 54.2%. Stool frequency at 48 hours in Racecadotril group were significantly decreased with a (mean of 5.10/SD 2.589/ P-value 0.012 as compared to Placebo (mean of 7.22 /SD 2.835). Mean age was 9.8 months. females were 45.8% whereas males were 54.2%. Stool frequency at 48 hours in Racecadotril group were significantly decreased with a (mean of 5.10/SD 2.589/ P-value 0.012 as compared to Placebo (mean of 7.22 /SD 2.835). Length of hospital stay was lower in racedo category 76.40 hours /SD 31.08610/P – value: 0.029 as compared to placebo with a mean of.92.400 hours /SD 38.9816. Length of hospital stay was lower in racedo category 76.40 hours /SD 31.08610/P – value: 0.029 as compared to placebo with a mean of.92.400 hours /SD 38.9816.

Conclusion: We have concluded from this study that racecadotril can be effectively used for treating acute gastroenteritis in pediatric population. It decreases stool frequency that will reduce duration of hospital stay.

Key Words: Racecadotril¸ Treatment, Acute Watery Diarrhea, Children

Citation of article: Khan N, Muhammad QK, Kiramat Ullah, Fazil M, Ali A, Afridi RU. To Study the Efficacy of Racecadotril for Treatment of Acute Watery Diarrhea in Children. Med Forum 2020;31(6):40-43.