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  3. 8.Clinical Spectrum, Bacterological Profile and Antibiogram of Culture Proven Enteric Fever in a Private Sector Hospital in Lahore
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8.Clinical Spectrum, Bacterological Profile and Antibiogram of Culture Proven Enteric Fever in a Private Sector Hospital in Lahore

Abid Rafiq Chaudhry

ABSTRACT

Objective: To determine the Clinical spectrum, frequency of different salmonella strains and their  trends of antibiotic susceptibility of culture isolates in patients of culture proven enteric fever in children over one year period.

Study Design: Retrospective cross-sectional study

Place and Duration of Study: This study was conducted at the Fatima Memorial Hospital Lahore from January, 2020 to December, 2020 for a period of one-year.

Materials and Methods: The case record of all patients of both sex diagnosed with enteric fever on blood culture is being reviewed. All patients in the age group of one year to 15 years with a discharge diagnosis of enteric fever for admitted inpatient or from outpatient Department (OPD) were included in the study.

Results: Mean age was around five year (61 months) and slight female preponderance (55%) was observed. Mean duration of fever before presentation was eight days and anorexia (82%) was the most common symptom after fever. S. Typhi was found in 76.4% of positive blood cultures and 23.6% of positive culture found S.Paratyphi A,B,C. 5 % cases of enteric fever  were multi sensitive  with 93% of isolates were either multidrug resistant(41%) or Extended drug resistant (52%).

Conclusion: Salmonella typhi is the predominantly isolated organism in cases of enteric fever. Only 5% of isolates are multi sensitive, Extended drug resistance (XDR typhoid) is the most commonly isolated organism with 52% of cases and 41% isolates were resistant to 1st line antibiotics (MDR typhoid). Study recommends azithromycin   for OPD patients (sensitivity 98%) or intravenous meropenem (sensitivity 100%)   for sick children in hospitals waiting for final culture and sensitivity reports to come.

Key Words: Clinical Spectrum, Bacterological Profile, Antibiogram of Culture, Enteric Fever

Citation of article: Chaudhry AR. Clinical Spectrum, Bacterological Profile and Antibiogram of Culture Proven Enteric Fever in a Private Sector Hospital in Lahore. Med Forum 2022;33(2):34-38.