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  3. 6. Prevention of Emergence Agitation with Dexmedetomidine in the Patients Undergoing Nasal Surgery Under Anesthesia with Desflurane
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6. Prevention of Emergence Agitation with Dexmedetomidine in the Patients Undergoing Nasal Surgery Under Anesthesia with Desflurane

Syed Aushtar Abbas Naqvi1, Mirza Shakeel Ahmad1 and Zeeshan Khan2

ABSTRACT

Objective: To evaluate the effectiveness of Dexmedetomidine in the avoidance of emergence agitation occurring in the patients enduring nasal surgery under anesthesia with Desflurane.

Study Design: A randomized controlled trial study.

Place and Duration of Study: This study was conducted at the Department of Anesthesia and intensive care of DG khan/Sheikh Zaid Medical College & Hospital Rahimyar Khan, from May 2018 to August 2018.

Materials and Methods: Sixty patients were distributed into two equal groups, Dexmedetomidine was given to one while the other received normal saline as placebo. Primary outcomes included incidence of emergence agitation while hemodynamic stability, postoperative sedation, pain severity, analgesics and anti-emetics requirements, stay in PACU were included in secondary outcomes. The data was entered in SPSS v.23 and analyzed with independent ttest, Mann Whitney U-test and Chi-square test, as appropriate. P≤0.05 was considered statistically significant. Results: Incidence of emergence agitation was 60% in group-N and 10% in group-D (p<0.001). Time to extubate, to attain BIS-90 and to get verbal reaction were prolonged in group-D (p<0.001). Stay time at PACU was considerablyextended in group-D (p=0.017). Ramsey sedation score was greater in Group-D than in group-N (p=0.016). The incidence of analgesics and anti-emetics use in PACU was 33.3% and 30% in group-N; and 10% and 6.7% in group-D, (p-value 0.028 and 0.020), respectively.

Conclusion: Dexmedetomidine is efficacious in reducing the occurrence of EA in the adult patients undergoing nasal surgery under general anesthesia with Desflurane but the degree of sedation is increased along with prolonged PACU stay.

Key Words: Emergence agitation, Dexmedetomidine, Desflurane, Nasal surgery

Citation of article: Naqvi SAA, Ahmad MS, Khan Z. Prevention of Emergence Agitation with Dexmedetomidine in the Patients Undergoing Nasal Surgery Under Anesthesia with Desflurane. Med Forum

 

2021;32(2):24-28.