5.Effect of Rosuvastatin Alone and Combination with Omega-3 Fatty Acid on Cholesterol and Fasting Blood Glucose Levels in Hypercholesterolemic and Diabetic Patients
Aziz Ahmed Solangi1, Gunesh Kumar2, Naveeta Rathi1, Nasreen Qazi1, Muhammad Azhar Mughal3 and Qamar Zaman1
Objective: To compare the effect of rosuvastatin and rosuvastatin omega-3 fatty acid on serum cholesterol and fasting blood glucose levels in hypercholesteremic and diabetic patients.
Study Design: Cross-Sectional Study
Place and Duration of Study: This study was conducted at the department of pharmacology and therapeutics with the collaboration of Cardiology OPD and ward LUHMS Jamshoro/Hyderabad for six months from March, 2020 to September, 2020.
Materials and Methods: Serum cholesterol & fasting blood sugar level was done from gel tubes bottles by using serum after centrifugation at 3,500 revolutions per minute for 10 minutes. The data was entered and analyzed using SPSS version 23.0.
Results: In this study total of 240 patients of hypercholesteremia and diabetics were studied. patients were divided into two groups as per treatment. Baseline serum cholesterol and fasting blood sugar were found to be statistically insignificant in both groups. After 30 days’ average serum cholesterol was significantly decreased 201.55+28.19 mg/dL in group B, as compared to group A as 230.62+32.74 mg/dL (p-0.001). However, after 30 days’ average of FBS was statistically insignificant. After 60 days of treatment, the average serum cholesterol was significantly decreased to 180.17+18.10 mg/dL in group B, as compared to group A as 210.59+25.44 mg/dL (p-0.001). However, after 30 days’ average of FBS was decreased but still statistically insignificant according to study groups (p-0.451).
Conclusion: It was concluded that serum cholesterol significantly decreased among the combined treatment group. Administration of Omega-3 fatty acids play important role in preventing hyperglycemia among statin treatment patients.
Key Words: Serum cholesterol, FBS, rosuvastatin, mega-3 fatty acid
Citation of article: Solangi AA, Kumar G, Rathi N, Qazi N, Mughal MA, Zaman Q. Effect of Rosuvastatin Alone and Combination with Omega-3 Fatty Acid on Cholesterol and Fasting Blood Glucose Levels in Hypercholesterolemic and Diabetic Patients. Med Forum 2021;32(12):19-23.