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  3. 45. Relevance of High Sensitivity C-Reactive Protein (hs-CRP) Level in Patients with Acute Coronary Syndrome (ACS) and Short Term Outcome
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45. Relevance of High Sensitivity C-Reactive Protein (hs-CRP) Level in Patients with Acute Coronary Syndrome (ACS) and Short Term Outcome

Gul Hassan Brohi1, Shahzeb Rasool Memon2, Shahbaz Ali Shaikh3, Kamran Ali Shahani4, Sarfraz Hussain Sahito3 and Mukhtiar Abro5

ABSTRACT

Objective: To evaluate the relevance of High Sensitivity C-Reactive Protein (hs CRP) level in patients with acute coronary syndrome (ACS) and short term outcome.

Study Design: Cross-sectional study.

Place and Duration of Study: This study was conducted at the Department of Cardiology, Liaquat University Hospital Hyderabad for six months from 15th March 2018 to 14th September 2018.

Materials and Methods: The ACS (ST elevated Ml, non-ST elevated MI, and Unstable Angina) patients were confirmed based on clinical history, ECG, Cardiac Enzymes, cardiac markers (Troponins), and further evaluated for hs-C-reactive protein levels. The data were analyzed in SPSS version 16.

Results: A total of 60 patients with acute coronary syndrome were recruited i.e. 40(00.7) STEML, 14(23.3%) NSTEMI, and 6(10%) unstable angina. The mean CRP level of intermediate-risk was 2.51±0.51, p<0.001, high-risk 10.95+7.7, pp<0.001, and low risk 0.862±0.51. There are significant values (<0.05), and 2(9.5%) died in the low-risk group. Six (85.7%) alive and 14 (43.75%) die in a high-risk group, 4 (19%) in the low-risk group, 1(14.3%) in the intermediate-risk group, and 8(25%$) high-risk group were hospitalized within three months. The mean ± SD of CRP with STEMI, NSTEMI, and UA was 6.82±8.0, 5.11±5.9, and 4. 63±8.2 (p=0. 05).

Conclusion: Serum hs-CRP levels show a significant correlation with the acute coronary syndrome. Measurement of C-reactive protein may have clinical significance in the management of patients hospitalized for the confirmed acute coronary syndrome.

Key Words: C-reactive protein, acute coronary syndrome, short-term outcome, high sensitivity.

Citation of article: Brohi GH, Memon SR, Shaikh SA, Shahani KA, Sahito SH, Abro M. Relevance of High Sensitivity C-Reactive Protein (hs-CRP) Level in Patients with Acute Coronary Syndrome (ACS) and Short Term Outcome. Med Forum 2020;31(12):191-195.