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40. Evaluation of Serum Uric Acid Levels in Idiopathic Lichen Planus Patients

Hira Mughal1, Saima Liaqat 1, Sana Khan1, Shakeel Ahmed Sheikh2, Hafiz Bashir Ahmed Kalhoro1 and Muhammad Suleman Pirzado2

ABSTRACT

Objective: To determine mean uric acid (UA) level in patients with lichen planus (LP) presenting at the department of Dermatology, Liaquat University Hospital Hyderabad.

Study Design: Descriptive Cross-sectional study

Place and Duration of Study: This study was conducted at the department of Dermatology, Liaquat University Hospital Hyderabad from October 17, 2017 to April 16, 2018.

Materials and Methods: This study was conducted on patients who met the inclusion criteria. A total of 95 patients diagnosed with LP admitted to the medical ward were enrolled and entered the study. After taking detailed history and full clinical examination (general and local), patients were subject to relevant investigations i.e. serum uric acid level was done. Patient’s height, weight, BMI, economic status and duration of disease in months was stated. From each patient 5 ml of venous blood sample was taken postprandially and sent to the institutional pathological laboratory for measuring of serum uric acid level. Each report was prepared by a consultant pathologist having at least more than 3 year of experience post fellowship.

Results: Age range in this study was from 20 to 50 years with mean age of 32.5 ± 4.47 years, mean BMI was 22.5 ± 3.47 in kg/m2 and mean duration of disease was 37 ± 18.92 in weeks. The mean serum UA level in Patients with Idiopathic Lichen Planus was 4.32 + 0.79mg/dL.

Conclusion: Our study results indicate that LP may be associated with the depletion of serum UA levels.UA can be considered a valuable antioxidant biomarker in LP for the development and monitoring of the treatment strategy.

Key Words: Serum Uric Acid, Lichen Planus,Intercellular Adhesion Molecule-1, Dermatology

Citation of article: Mughal H, Liaqat S, Khan S, Sheikh SA, Kalhoro HBA, Pirzado MS. Evaluation of Serum Uric Acid Levels in Idiopathic Lichen Planus Patients. Med Forum 2021;32(3):163-167.