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  3. 4. The Prevalence of Liver Diseases and Etiological Factors among the Patients of Jinnah Post Graduate Medical Centre (JPMC), Karachi
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4. The Prevalence of Liver Diseases and Etiological Factors among the Patients of Jinnah Post Graduate Medical Centre (JPMC), Karachi

Mubashira Hashmi1, Bhawani Shanker2, Kashif Faisal3 and Shenaz Imdad Kehar4

 

ABSTRACT

 

Objective: To determine the frequency and etiological factors of nonneoplastic and neoplastic liver diseases

Study Design: Observational / analytic study.

 

Place and Duration of Study: This study was conducted at the Department of Pathology, BMSI, JPMC from 1st January 2012 to 31st September 2014.

 

Materials and Methods: A total of 288 liver biopsycases of formalin fixed liver tissue biopsies were selected and analyzed for morphological features and grading received from January 2010-December 2012, at the department of Pathology, Basic Medical Sciences Institute, Jinnah Post Graduate Medical Centre.

 

Most common liver disease was CLD (88.54%). Most common age for CLD was between 3rd-5th decades of life with male predominance. HCV was the most common etiological factor. Out of total cases, 6.59% were hepatocellular and bile duct carcinomas. Most common age for liver cancers was 5th-7th decade of life with male predominance. The data feeding and analysis were on computer package SPSS (Statistical Packages of Social Sciences) version 20.0. In all statistical analysis only p-value <0.05 was considered significant. Results: The most commonly encountered liver disease CLD was f und as a major liver disease (71%) of the samples were suffering from CLD , while 25 % were suffering from HCC, He atitis C was the major cause of the liver diseases, (55.56%) of the liver patients were earlier suffering from the Hepatitis C.

 

Conclusion: In conclusion we observed that the most common liver disease in bi psy cases is chronic liver disease (chronic hepatitis), mostly occur between 21-50 years of age with male predominance and most frequent etiological factor is HCV.

Key Words: Liverdiseases, non-neoplastic liver diseases, neoplastic liver diseases

 

Citation of article: Hashmi M, Shanker B, Fa sal K, Kehar SI. The Prevalence of Liver Diseases and Etiological Factors among the Patients of Ji ah Post Graduate Medical Centre (JPMC), Karachi. Med Forum 2016;27(7):13-17.