Search Submit Your Manuscript

Become A Member

  1. Home
  2. January 2018
  3. 4. Comparison of Efficacy of Fosfomycin and Ceftriaxone in the Treatment of Urinary Tract Infections in Children
Article Image
Admin

4. Comparison of Efficacy of Fosfomycin and Ceftriaxone in the Treatment of Urinary Tract Infections in Children

Arshia Munir1, Muhammad Aqeel Khan1, Muhammad Bilal Khattak2, Kalimullah Khan3 and Irum Naz4

ABSTRACT

Objective: To compare the efficacy of oral Fosfomycin and Intravenous ceftriaxone in the treatment of urinary tract infections (UTIs) in children upto 16 years of age.

Study Design: Randomized Clinical Trial (RCT)

Place and Duration of Study: This study was conducted at the Department Pediatrics, MTI HMC Peshawar from November 2016 to April 2017.

Materials and Methods: 390 children with UTI were randomly allocated in two groups A (195) to receive fosfomycin and B (195) to receive ceftriaxone. Urine culture was done at the 5th day of the start of therapy to determine the effect of drug.

Results: We found the mean age group of our whole sample was 9.4 ± 2.3 years. The mean age of children in group A was 9.4 ± 2.4 years while in group B it was 9.3 ± 2.2 years (p 0.949). There were 61.5% males in group A compared to 67.7% in group B (p 0.204). On follow up, repeat urine culture was performed in all children and it was observed that 72.3% children in fosfomycin group and 60% children in ceftriaxone group were having negative urine culture (efficacy) p 0.01.

Conclusion: Fosfomycin is effective compared to ceftriaxone in the treatment of UTIs (urinary tract infections) in children.

Key Words: Urinary Tract Infection, Urine Culture, Pyrexia, Fosfomycin, Ceftriaxone, Abbreviations: HMC: Hayatabad Medical Complex, C & S: culture and sensitivity, UTI: Urinary tract infection.

Citation of articles: Munir A, Khan MA, Khattak MB, Khan K, Naz I. Comparison of Efficacy of Fosfomycin and Ceftriaxone in the Treatment of Urinary Tract Infections in Children. Med Forum 2018;29(1):14-17.