4. Comparative Study of Bevacizumab and Triamcenolone in Macular Edema Secondary to Branch Retinal Vein Occlusion
Shahnawaz Channa, Ameer Ahmed Memon and Farhan Khashim Al-Swailmi
Objective: The present study was conducted to compare the magnitude of efficacy and safety of Intra-Vitreal Bevacizumab (IVB) and intra-vitreal Triamcenolone (IVT) injection in Branch Retinal Vein Occlusion (BRVO).
Study Design: Comparative case series study Place and Duration of Study: This study was conducted at the Department of Ophthalmology, El-Ibrahim Eye Hospital and Al-Tibri Medical College from January 2013 to March 2015.
Materials and Methods: A sample of 64 BRVO cases was selected by non-probability purposive sampling as per inclusion and exclusion criteria. The subjects were randomly grouped into; Group I. Bevacizumab (IVB) (n=32) and Group II. Triamcinolone (IVT) (n=32). Baseline vision (BCVA) was noted using ETDRS acuity chart. Central macular thickness (CMT) was computed using optical coherence tomography (OCT). Informed written consent was taken. The data was analyzed on Statistix 8.1 using student t-test and Chi square test. P-value of ≤0.05 was taken significant.
Results: Mean± SD CMT in group I and II at baseline was 365.71±159.7µ and 363.91±153.9µ respectively (p=0.95). Similarly, difference was not observed in BCVA for near between 2 groups at first and second visit (week 4) (p≥0.85). At week 8 follow up, there was significant difference in the BCVA between groups (for distance p = 0.03 and for near (p = 0.017). At week 8, mean CMT was reduced in IVB group compared to IVT (p=0.045). Mean± SD duration of BRVO was 8.37±4.21 and 8.35±4.3 months (p=0.09) in IVB and IVT respectively. Subconjuctival hemorrhage, cataract and raised IOP were observed in IVT group.
Conclusion: Bevacizumab is more effective than triamcinolone in improving vision and reducing macular edema secondary to Branch Retinal Vein Occlusion. Triamcinolone showed more complications.
Key Words: Bevacizumab, Triamcinolone, Macular edema Citation of article: Channa S, Memon AA, Al-Swailmi FK. Comparative Study of Bevacizumab and Triamcenolone in Macular Edema Secondary to Branch Retinal Vein Occlusion. Pakistan. Med Forum 2017;28(2):15-18.