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  3. 33. Effect of Peri-Operative Dexmedetomidine on Incidence of Delirium in Elderly Patients After Cardiac Surgery
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33. Effect of Peri-Operative Dexmedetomidine on Incidence of Delirium in Elderly Patients After Cardiac Surgery

Syed Imran-ul-Hassan, Zehra Hasnain, Kanwal Awan, Maryam Liaquat, Maria Ikram and Javairia Saleem

ABSTRACT

Objective: The aim of this study was to compare the frequency of delirium in patients of elective cardiac surgery treated peri operatively with dexmedetomidine with those treated with midazolam.

Study Design: Randomized controlled trial study.

Place and Duration of Study: This study was conducted at the Department of cardiac surgery, Punjab Institute of Cardiology, Lahore, Pakistan from July, 2020 till December, 2020.

Materials and Methods: Dexmedetomidine was given to half of the patients included in the study and other drug was taken as a controlled drug, Midazolam.The objective of this study was to compare the frequency of delirium in patients of elective cardiac surgery treated with peri operatively with dexmedetomidine with those treated with midazolam prei-operatively. Delirium was assessed using the scale - MMSE Scoring scale. Mini-Mental State Examination (MMSE) Score is of total 30 score. Patients were asked some questions in the form of an interview and 1 mark was given for each correct answer. Any patient with a score of less than 24 was labeled as having a cognitive impairment or delirium.

Results: The comparison of frequency of deliriumin patients of cardiac surgery treated with perioperative dexmedetomidine vs midazolam was done, 8.57% (n=2) in Dexmedetomidine group and 22.86%(n=8) in midazolam group were found with delirium, p value was 0.04.

Conclusion: Delirium is a stressful complication observed in the post-operative period. With the use of dexmedetomidine along with the induction of general anesthesia, the chances of post-operative delirium can be reduced. This trial should be done on a larger scale documenting the effects of DEX on all the parameters monitored during the general anesthesia.

Key Words: Peri-Operative Dexmedetomidine, Incidence of Delirium, Elderly Patients, Cardiac Surgery

Citation of article: Hassan SI, Hasnain Z, Awan K, Liaquat M, Ikram M, Saleem J. Effect of Peri-Operative Dexmedetomidine on Incidence of Delirium in Elderly Patients After Cardiac Surgery. Med Forum


2021;32(2):142-146.