3. Incidence of Hyperamylasemia Leading to Respiratory Failure in Patients of Organophosphate Poisoning
Akhtar Ali1, Umer Khan1, Munir Hussain Siddique3, Jawwad us Salam2, Faiza Ghuman1, Mohammad Masroor1 and Syed Mohammad Adnan4
ABSTRACT
Objective: To determine the frequency of Hyperamylasemia leading to respiratory failure in patients of organophosphate poisoning.
Study Design: Observational / descriptive study.
Place and Duration of Study: This study was conducted at the Department of Medicine Dow University of Health Sciences, Karachi from June 2014 to June 2015.
Materials and Methods: A total of 168 patients of Organophosphate poisoning fulfilling the inclusion criteria were included in the study. Blood was drawn after aseptic measures by a trained phlebotomist for Serum Amylase level and Arterial blood gases. Value more than 101U/L was taken as hyperamylasemia. PaO2 less than 60mmHg or PCO2 greater than 55mg was labeled as respiratory failure. All information was noted on proforma.
Results: There were 59% were male and 41% were female. Frequency of h eram lasemia in patients of organophosphate poisoning was 44%. Frequency of respiratory failure in hy eramylasemia in patients was observed in 68%. Respiratory failure was significantly high in male than female (70% vs. 30%; =0.019).
Conclusion: Hyperamylasemia is more frequently seen in organoph sphate p is ning. In patients with respiratory failure the mortality is very high; therefore we recommended early diagn sis, careful monitoring and appropriate management of complications in reducing the mortality rate.
Key Words: Organophosphate, Respiratory failure, Hyperamylasemia
Citation of article: Ali A, Khan U, Siddique MH, Salam J, Ghuman F, Masroor M, Adnan SM. Incidence of Hyperamylasemia Leading to Respiratory Failure Pat ents of Organophosphate Poisoning. Med Forum 2016;27(6):10-13.