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  3. 3. Frequency of Kernicterus in Rh Incompatibility after Receiving Effective Phototherapy and Intravenous Immunoglobulin Therapy
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3. Frequency of Kernicterus in Rh Incompatibility after Receiving Effective Phototherapy and Intravenous Immunoglobulin Therapy

Saima Ali1, Muhammad Aqeel Khan1, Arshia Munir2, Mukhtar Ahmad Afridi3 and Waqar Azeem Siddiqi4 and Kashif Ali3

ABSTRACT

Objective: To compare Frequency of Kernicterus in Rh incompatibility after receiving effective phototherapy and Intravenous immunoglobulin therapy.

Study Design: Randomized Controlled Trial study

Place and Duration of Study: This study was conducted at the Special Care Baby Unit, Department of Pediatrics Medicine, HMC, Peshawar from January, 2021 to June, 2021.

Materials and Methods: A total of 152 neonates with jaundiced due to Rh incompatibility and fulfilling the inclusion criteria were included in the study and were randomly assigned to two groups A and B. Phototherapy and Immunoglobulin therapy was used for group A and B respectively. The patients were observed for response to therapy.  .Data was analyzed by SPSS version 23.

Results: Majority of the individuals were male that is 71.1% in group B while females were more (65.8%) in group A. mean age of neonates in group A (phototherapy) were 13.67±6.46 days and group B (IVIG) were 14.18±5.94 days respectively.  Mean duration of jaundice in group A was 3.76±1.24 days compared to group B 3.78±1.11 days. Mean gestational age was observed as 35.63±2.33 and 36.53±1.99 weeks at birth.

Kernicterus was more prevalent in group A (69.7%). Gestational age was found to be significantly (p<0.05) associated with kernicterus. Intravenous immunoglobulin treatment was found more effective (p<0.05) therapy.

Conclusion: Immunoglobulin therapy is more effective in reducing the number of Kernicterus in neonates with hemolytic diseases of the newborn.

Key Words: Neonatal Jaundice, Kernicterus, Phototherapy, Immunoglobulins

Citation of article: Ali S, Khan MA, Munir A, Afridi MA, Siddiqi WA, Ali K. Frequency of Kernicterus in Rh Incompatibility after Receiving Effective Phototherapy and Intravenous Immunoglobulin Therapy. Med Forum 2023;34(2):11-14.